M H de Keijzer, B S Jakobs, R W Brandts, M T Hofs, F J Trijbels, J A Smeitink
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Rapid and reliable measurement of highly elevated blood ammonia concentrations in children.
Newborns and children may suffer from extremely high ammonia levels in their blood. We evaluated a fast, reliable micromethod, based on the Blood Ammonia Checker II (BAC II) in combination with the dilution with fresh whole blood. Comparison of the proposed method with an enzymatic method revealed a statistically significant correlation. We conclude that the dilution of patient's blood with fresh whole blood extends the measuring range of ammonia on the BAC II analyzer from 286 mumol/l to about 700 mumol/l.
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