中性粒细胞减少患者严重感染粘液口球菌1例报告及文献复习。

Hematology and cell therapy Pub Date : 1998-08-01
D Gruson, G Hilbert, A Pigneux, F Vargas, O Guisset, J Texier, J M Boiron, J Reiffers, G Gbikpi-Benissan, J P Cardinaud
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引用次数: 0

摘要

24岁女性,急性髓性白血病化疗后中性粒细胞减少期(第15天),因感染性肺炎入住重症监护病房。从外周血培养物中分离到两株粘液口球菌。支气管肺泡灌洗未检出微生物。经及时有效的抗生素治疗,患者病情好转。这是我们单位第一例因黏液口球菌引起的败血症和肺炎。仅有26例发生在中性粒细胞减少患者的潜在血液恶性肿瘤的文献报道,其中只有5例肺炎被描述。这种人类口腔正常居民的并发症可能是严重和致命的:感染性休克、脑膜炎、急性呼吸窘迫综合征。本研究阐明了黏液口球菌对中性粒细胞减少患者可能的毒力。
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Severe infection caused by Stomatococcus mucilaginosus in a neutropenic patient: case report and review of the literature.

A 24-year-old female, in neutropenic phase after chemotherapy for acute myelogenous leukemia (on day 15) was admitted in intensive care unit for infectious pneumonia. Two strains of Stomatococcus mucilaginosus were isolated from peripheral blood cultures. No microorganisms were yielded from bronchoalveolar lavage. Patient's condition improved with prompt instigation of effective antibiotic therapy. This was the first case of septicemia and pneumonia, due to Stomatococcus mucilaginosus, in our unit. Only 26 cases occurring in neutropenic patients with underlying hematologic malignancies were reported in the literature and among these, only five cases with pneumonia were described. The complications of this normal inhabitant of the human oral cavity can be serious and fatal: septic shock, meningitis, acute respiratory distress syndrome. This study illustrate the possible virulence of Stomatococcus mucilaginosus in neutropenic patients.

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