{"title":"橙皮苷对小鼠皮肤肿瘤发生和促进的抑制作用。","authors":"B Berkarda, H Koyuncu, G Soybir, F Baykut","doi":"10.1007/s004330050093","DOIUrl":null,"url":null,"abstract":"<p><p>A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hesperidin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.</p>","PeriodicalId":76421,"journal":{"name":"Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie","volume":"198 2","pages":"93-9"},"PeriodicalIF":0.0000,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s004330050093","citationCount":"63","resultStr":"{\"title\":\"Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin.\",\"authors\":\"B Berkarda, H Koyuncu, G Soybir, F Baykut\",\"doi\":\"10.1007/s004330050093\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hesperidin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.</p>\",\"PeriodicalId\":76421,\"journal\":{\"name\":\"Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie\",\"volume\":\"198 2\",\"pages\":\"93-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s004330050093\",\"citationCount\":\"63\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s004330050093\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s004330050093","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 63
摘要
一种黄酮类化合物橙皮苷在CD-1小鼠皮肤中具有抑制多环芳烃引发肿瘤和抑制酚酯促进肿瘤的能力。皮下应用橙皮苷不能抑制7,12-二甲基苯(a)蒽诱导的肿瘤启动，但可以抑制12- o -十四烷醇-13-磷酸酯诱导的肿瘤促进。结果表明橙皮苷具有潜在的化学预防作用。
Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin.
A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hesperidin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.
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