{"title":"作为桥接核苷的前药的合成。","authors":"J Hatlelid, T Benneche, K Undheim","doi":"10.3891/acta.chem.scand.52-1270","DOIUrl":null,"url":null,"abstract":"<p><p>Methods for the preparation of N,N'-connected bisnucleosides have been developed. The bridge is formally a carbonate ester of N-hydroxymethyl nucleosides. Both symmetrical and non-symmetrical bridged bisnucleosides are available.</p>","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"52 10","pages":"1270-4"},"PeriodicalIF":0.0000,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Synthesis of prodrugs as bridged nucleosides.\",\"authors\":\"J Hatlelid, T Benneche, K Undheim\",\"doi\":\"10.3891/acta.chem.scand.52-1270\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Methods for the preparation of N,N'-connected bisnucleosides have been developed. The bridge is formally a carbonate ester of N-hydroxymethyl nucleosides. Both symmetrical and non-symmetrical bridged bisnucleosides are available.</p>\",\"PeriodicalId\":76966,\"journal\":{\"name\":\"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)\",\"volume\":\"52 10\",\"pages\":\"1270-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3891/acta.chem.scand.52-1270\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3891/acta.chem.scand.52-1270","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Methods for the preparation of N,N'-connected bisnucleosides have been developed. The bridge is formally a carbonate ester of N-hydroxymethyl nucleosides. Both symmetrical and non-symmetrical bridged bisnucleosides are available.
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