[三磷酸肌醇在t淋巴细胞钙信号形成中的作用]。

O P Matyshevskaia
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引用次数: 0

摘要

讨论了TCR/CD3复合物和磷脂酶C相互作用的机制,肌醇1,4,5-三磷酸在细胞内Ca2+的初始瞬时和持续升高以及T细胞刺激后钙振荡驱动中的作用。本文综述了ip3受体在淋巴细胞中的结构和定位。
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[Role of inositol triphosphate in the formation of the calcium signal in T-lymphocytes].

The mechanisms of TCR/CD3 complex and phospholipase C interaction, inositol-1,4,5-triphosphate role in both initial transient and sustained elevation of intracellular Ca2+ and in calcium oscillations driving following T cells stimulation are discussed. Data on IP3-receptors structure and localisation in lymphocytes are summarized.

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