大鼠α -亚麻酸缺乏时听觉脑干反应的变化与年龄的关系。

J M Bourre, G Durand, J P Erre, J M Aran
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引用次数: 35

摘要

研究人员比较了幼鼠(21日龄)、成年鼠(6个月大)和老年鼠(18个月大)对点击刺激的听觉脑干反应(ABRs),分别饲喂正常(花生酸-油菜)或α -亚麻酸缺乏(仅花生酸)的饮食。波I振幅和潜伏期随年龄和饮食没有明显变化。然而,第三波显示振幅和潜伏期从年轻到成年和从成年到老年饮食正常的大鼠逐渐减少。α -亚麻酸缺乏时,波III振幅和潜伏期值比正常饮食对照组下降得更快。虽然两种饮食的老年组的最终值相似,但第三波α -亚麻酸缺乏值在成年组中下降到最终水平。这些数据表明,在脂肪酸缺乏的情况下,中枢听觉神经系统衰老得更快或更早。
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Changes in auditory brainstem responses in alpha-linolenic acid deficiency as a function of age in rats.

Auditory brainstem responses (ABRs) to click stimuli have been compared in young (21-day-old), adult (6-month-old), and old (18-month-old) rats fed a normal (Arachid-Colza) or an alpha-linolenic acid deficient (Arachid only) diet. Wave I amplitude and latency did not show any significant change with either age or diet. However, wave III showed a progressive decrease in amplitude and latency from young to adult and from adult to old rats having a normal diet. With alpha-linolenic acid deficiency, wave III amplitude and latency values decreased faster than in the normal diet control groups. Although final values in the old groups with the two diets were similar, with alpha-linolenic acid deficiency values for wave III decreased to this final level in the adult group. These data indicate that the central auditory nervous system ages faster, or earlier, with a fatty acid deficiency.

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