[暴露于某些外源药物和低剂量辐射作用后大鼠肝脏线粒体脂质过氧化指标]。

I A Kanapatskaia, T N Zyrianova, V M Lavrova
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引用次数: 0

摘要

以硝酸钠、亚硝酸钠和亚硝基二乙胺为背景,研究了0.5 Gy γ辐照后1、7和15 d大鼠肝脏线粒体脂质过氧化一级和二级产物的含量。结果表明,在硝酸钠、亚硝酸钠和亚硝基二乙胺背景下的γ辐照改变了硝基化合物对脂质过氧化速度的影响。此外,硝酸钠与γ辐照的联合作用比单独因素的影响更有效果。观察到的脂质过氧化产物数量的变化相当稳定,并在所有监督期间保持不变。
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[Indicators of lipid peroxidation in rat liver mitochondria after exposing them to some xenobiotics and the action of low dose radiation].

The contents of primary and secondary products of lipid peroxidation in rat liver mitochondria through 1, 7 and 15 days after gamma-irradiation in a dose 0.5 Gy on a background of consumption of sodium nitrate, sodium nitrite and nitrosodiethylamine was investigated. Is was shown, that gamma-irradiation on a background of sodium nitrate, sodium nitrite and nitrosodiethylamine modified effects of nitrocompounds on speed of lipid peroxidation. Besides, combine action of sodium nitrate and gamma-irradiation has more effect in comparison with influencing of separate factors. The observed changes in quantity of lipid peroxidation products are rather stable and are kept during all terms of supervision.

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