结直肠癌中p53蛋白、c- erbb -2表达与细胞凋亡的关系

Q He, Y Ohaki, N Tanaka, G Asano
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摘要

为了阐明肿瘤侵袭前段肿瘤生长与各种基因表达及凋亡发生的关系,我们对57例晚期结直肠癌进行了p53、c- erbb -2免疫组化染色、TUNEL法及电镜观察。光镜下,腺癌的柱状上皮细胞在肿瘤侵袭前沿常表现为高的减少和向腔内脱落。免疫组化结果显示,高血管浸润组p53、c- erbb -2阳性表达率高于低血管浸润组(p < 0.05)。血管或淋巴浸润与p53和c- erbb -2阳性免疫反应性密切相关。细胞凋亡指数与血管侵袭、p53过表达和肿瘤侵袭前部周围的炎症细胞浸润有关。这些结果表明p53。c- erbb -2和凋亡指数应与结直肠癌预后因素结合评估。浸润性炎性细胞可诱导肿瘤细胞凋亡。
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[The relationship between p53 protein and c-erb B-2 expression and apoptosis in colorectal cancer].

In order to elucidate the relationship between tumor growth and various kinds of gene expression and the occurrence of apoptosis in the front portion of neoplastic invasion, 57 advanced colorectal cancers were studied by immunohistochemical staining of p53, c-erb B-2, the TUNEL method and electron microscopy. Light microscopically, the columnar epithelial cells of adenocarcinoma frequently showed a decrease in high and a fall off into the lumen in tumor invasive forefront. Immunohistochemically the positive rate of p53 and c-erb B-2 in tumors with high vascular invasion were higher (p < 0.05) than in those with low vascular invasion. There was a close correlation between the vascular or lymphatic invasion and positive immunoreactivity of p53 and c-erb B-2. The apoptosis index was demonstrated to be related to vessel invasion, over expression of p53 and inflammatory cell infiltration around the front portion of the tumor invasion. These results suggested that p53. c-erb B-2 and the apoptosis index should be evaluated in conjunction with the prognostic factors in colorectal cancer. The infiltrative inflammatory cells may induce apoptosis of the tumor cells.

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