[动物实验中乙醛对酒精依赖形成的影响]。

N K Kharchenko
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引用次数: 0

摘要

对实验动物持续给予乙醛的实验结果表明,乙醛可以诱导大脑结构/下丘脑的细胞质部分的乙醛脱氢酶活性。中脑和新脑皮层/以及生物胺/去甲肾上腺素和5-羟色胺水平/在相同的结构中同时在实验动物乙醛酒精依赖下形成酒精依赖。研究了乙醇脱氢酶及其作用的变化。
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[Effect of acetaldehyde on the formation of alcohol dependence in animal experiments].

As a result of the experiment on the laboratory animals under the continuous administration of acetaldehyde there has been revealed the latter as inducing the aldehyde dehydrogenase activity in the cytosol fraction of the cerebral structures/hypothalamus, mid-brain and new cerebrum cortex/as well as in the levels of biogenic amines/noradrenaline and 5-hydroxytryptamine/in the same structures while forming experimentally in the laboratory animals the alcoholic dependence under acetaldehyde alcoholic dependence. The work displays some changes of alcohol dehydrogenase and action.

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