腹腔内温度对大鼠腹腔内顺铂组织和肿瘤扩散的影响

IF 0.6 4区医学 Q4 SURGERY Chirurgie Pub Date : 1999-09-01 DOI:10.1016/S0001-4001(00)80009-4

L. Benoit , C. Duvillard , P. Rat , B. Chauffert

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引用次数: 28

摘要

目的探讨高热、低温对腹膜及顺铂腹腔内穿透肿瘤的影响。材料与方法用1 × 106个DHD/K12/PROb细胞腹腔注射大鼠，获得20日龄腹膜癌。各组动物腹腔输注顺铂(25 μg/mL)，分别采用高温(16.6°C)、常温(37.6°C)或高温(41.8°C)腹腔化疗。结果与常温治疗相比，低温使肿瘤和膈组织中的顺铂浓度升高，而肾脏中的顺铂浓度降低。与常温治疗相比，低温治疗在癌症和腹膜组织中产生较低的顺铂浓度。结论这些实验证实了热疗在顺铂腹腔化疗中的药理优势。

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Effets de la température intra-abdominale sur la diffusion tissulaire et tumorale du cisplatine intrapéritonéal dans un modèle de carcinose péritonéale chez le rat

Objective

To evaluate the effects of hyperthermia and hypothermia on the peritoneal and on tumor penetration by intraperitoneal cisplatin.

Material and methods

Twenty day old peritoneal carcinomatosis was obtained after intraperitoneal injection of 1 × 10⁶ DHD/K12/PROb cells into BD IX rats. Animals were treated by intraperitoneal infusion of cisplatin (25 μg/mL) using hyperthermie (16.6 °C), normothermie (37.6 °C) or hyperthermic (41.8 °C) intraperitoneal chemotherapy.

Results

Hyperthermia increased cisplatin concentration in tumoral and diaphragmatic tissues compared to normothermie treatment, while renal concentrations were lower. Hypothermia produced lower cisplatin concentrations in both cancer and peritoneal tissues compared to normothermie treatment.