封装片式双焦点RGP隐形眼镜下的氧气环境是怎样的?

T J Brunstetter, B A Fink, R M Hill
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摘要

背景:一种双焦点刚性透气性(RGP)隐形眼镜现在是可用的,完全封装了一个不同的材料在其较低的方面。本研究的目的是确定主晶状体及其包封段区域对角膜下层吸氧速率的影响。方法:在不佩戴的情况下,测量了10个人角膜的角膜吸氧率——包括中央角膜和下角膜——然后在300秒佩戴聚甲基丙烯酸甲酯(PMMA)镜片和这种rgp封装的部分双焦点隐形眼镜后立即测量。对这三种环境条件下的角膜反应进行统计比较(即,不受眨眼驱动泪液流的影响)。结果:维持不眨眼条件下(即仅限晶状体透性供氧),RGP双晶状体中央角膜缺氧仅为PMMA (Dk/L = 0)条件下的47%,而双晶状体包封段下角膜缺氧反应平均为PMMA (Dk/L = 0)条件下的78%。双焦点晶状体和PMMA晶状体的中心部位反应有显著差异(p < 0.001),这两种晶状体的中心部位反应也有显著差异(p < 0.001)。所有与晶状体相关的反应都与无晶状体的情况有显著差异(p < 0.001)。结论:使用Smith的模型(JAOA, 1997)来估计晶状体的透射率,这种RGP双焦点设计的主要晶状体似乎可以满足大约80%的Holden-Mertz日常佩戴氧气需求——即使没有晶状体后撕裂交换,但只有大约25%的需求似乎可以满足封装节段区域以下的需求。因此,通过眨眼驱动的泪液交换在晶状体下有效补充输注氧气对于维持最佳的角膜健康是必要的。
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What is the oxygen environment under an encapsulated segment bifocal RGP contact lens?

Background: A bifocal rigid gas permeable (RGP) contact lens is now available that totally encapsulates an add segment of a different material within its inferior aspect. The purposes of this study were to determine the effects of the major lens and of its encapsulated segment region on the oxygen uptake rates of underlying cornea.

Methods: Corneal oxygen uptake rates of 10 human corneas were measured--both centrally and inferiorly--for non-wearing conditions and then immediately after 300-second wearing periods of a polymethylmethacrylate (PMMA) lens and of this RGP-encapsulated segment bifocal contact lens. Corneal responses associated with these three environmental conditions were compared statistically (i.e., without the influence of blink-driven tear flow).

Results: Under the nonblinking conditions maintained (i.e., with oxygen availability restricted to lens transmissibility alone), central corneal hypoxia was found for the RGP bifocal lens to be only 47% of that induced by the PMMA (Dk/L = 0) condition, while the cornea under the encapsulated segment of the bifocal lens averaged 78% of the hypoxic response induced by that same condition. Central site responses were found to be significantly different for the bifocal and the PMMA lens (p < 0.001), as they were for the two inferior sites with these two lenses (p < 0.001). All lens-related responses were found to be significantly different from the no lens condition (p < 0.001).

Conclusions: Using Smith's model (JAOA, 1997) to estimate lens transmissibility, the major lens of this RGP bifocal design appears to meet approximately 80% of the Holden-Mertz daily-wear oxygen requirement--even without post-lens tear exchange, but only about 25% of that requirement appears to be met beneath the encapsulated segment region. Efficient supplementary infusion of oxygen under this lens by blink-driven tear exchange, then, is necessary to maintain optimal corneal health.

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