大蒜素对离体大鼠脑细胞内Ca2+浓度的影响。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-07-01

X H Ma, X X Pan, T P Liu

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引用次数: 0

摘要

目的:研究大蒜提取物大蒜素对离体大鼠脑细胞内钙的影响。方法:从新生大鼠脑中分离脑细胞，用Fura 2-AM测量细胞内Ca2+浓度([Ca2+]i)。结果:大蒜素1 ~ 100 μ mol。L-1浓度依赖性阻断氯化钾和谷氨酸钠(Glu)引起的[Ca2+]i升高，IC50分别为59.7和69.9 μ mol。l - 1。大蒜碱100毫摩尔。L-1阻断去甲肾上腺素(Nor)诱导的[Ca2+]i升高。结论:葱黄可有效阻断氯化钾、一氧化氮和谷氨酸引起的[Ca2+]i升高。

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Effects of allitridi on intracellular Ca2+ concentration in isolated rat brain cells.

Aim: To study actions of allitridi extracted from garlic on intracellular calcium in isolated rat brain cells.

Methods: Brain cells were isolated from newborn rat brain with Fura 2-AM measurements of intracellular Ca2+ concentration ([Ca2+]i).

Results: Allitridi 1-100 mumol.L-1 concentration-dependently blocked increases of [Ca2+]i caused by potassium chloride and sodium glutamate (Glu) with IC50 of 59.7 and 69.9 mumol.L-1 respectively. Allitridi 100 mumol.L-1 blocked norepinephrine (Nor)-induced [Ca2+]i elevation.

Conclusion: Allitridi is an effective agent for blocking the [Ca2+]i increase caused by potassium chloride, Nor and Glu.

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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