心脏手术的单剂量与多剂量抗生素预防。

The Australian and New Zealand journal of surgery Pub Date : 2000-06-01 DOI:10.1046/j.1440-1622.2000.01837.x

S J Bucknell, M Mohajeri, J Low, M McDonald, D G Hill

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引用次数: 50

摘要

背景:本研究旨在确定单剂量抗菌药物预防是否足以用于心脏手术。方法:该研究是一项前瞻性非随机试验，纳入353例连续接受心脏手术的患者。A组(n = 151)接受48小时的预防治疗，B组(n = 202)接受单剂量治疗。所有患者均使用头孢唑啉，但接受替柯planin和汀丁治疗的耐甲氧西林金黄色葡萄球菌(MRSA)高风险患者除外。结果:我院住院总感染率为2.8%。两组之间的感染率和感染类型无显著差异。结论:我院住院感染率为2.8%，优于其他系列报道。单剂量抗菌素预防与48小时治疗同样有效。针对高危人群是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Single-versus multiple-dose antibiotics prophylaxis for cardiac surgery.

Background: This study was carried out to determine if single-dose antimicrobial prophylaxis is sufficient for cardiac surgery.

Methods: The study was a prospective non-randomized trial of 353 consecutive patients undergoing cardiac surgery. Group A (n = 151) received 48 h of prophylaxis and Group B (n = 202) received a single dose. Cephazolin was used in all patients except those at high risk from methicillin-resistant Staphylococcus aureus (MRSA) who received teicoplanin and timentin.

Results: There was an overall in-hospital infection rate of 2.8%. There was no significant difference in rate or type of infection between the two groups.

Conclusions: An in-hospital infection rate of 2.8% compares favourably with other reported series. Single-dose antimicrobial prophylaxis is as effective as a 48-h regimen. Targeting high-risk groups is effective.

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