S J Bucknell, M Mohajeri, J Low, M McDonald, D G Hill
{"title":"心脏手术的单剂量与多剂量抗生素预防。","authors":"S J Bucknell, M Mohajeri, J Low, M McDonald, D G Hill","doi":"10.1046/j.1440-1622.2000.01837.x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study was carried out to determine if single-dose antimicrobial prophylaxis is sufficient for cardiac surgery.</p><p><strong>Methods: </strong>The study was a prospective non-randomized trial of 353 consecutive patients undergoing cardiac surgery. Group A (n = 151) received 48 h of prophylaxis and Group B (n = 202) received a single dose. Cephazolin was used in all patients except those at high risk from methicillin-resistant Staphylococcus aureus (MRSA) who received teicoplanin and timentin.</p><p><strong>Results: </strong>There was an overall in-hospital infection rate of 2.8%. There was no significant difference in rate or type of infection between the two groups.</p><p><strong>Conclusions: </strong>An in-hospital infection rate of 2.8% compares favourably with other reported series. Single-dose antimicrobial prophylaxis is as effective as a 48-h regimen. Targeting high-risk groups is effective.</p>","PeriodicalId":22494,"journal":{"name":"The Australian and New Zealand journal of surgery","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1440-1622.2000.01837.x","citationCount":"50","resultStr":"{\"title\":\"Single-versus multiple-dose antibiotics prophylaxis for cardiac surgery.\",\"authors\":\"S J Bucknell, M Mohajeri, J Low, M McDonald, D G Hill\",\"doi\":\"10.1046/j.1440-1622.2000.01837.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study was carried out to determine if single-dose antimicrobial prophylaxis is sufficient for cardiac surgery.</p><p><strong>Methods: </strong>The study was a prospective non-randomized trial of 353 consecutive patients undergoing cardiac surgery. Group A (n = 151) received 48 h of prophylaxis and Group B (n = 202) received a single dose. Cephazolin was used in all patients except those at high risk from methicillin-resistant Staphylococcus aureus (MRSA) who received teicoplanin and timentin.</p><p><strong>Results: </strong>There was an overall in-hospital infection rate of 2.8%. There was no significant difference in rate or type of infection between the two groups.</p><p><strong>Conclusions: </strong>An in-hospital infection rate of 2.8% compares favourably with other reported series. Single-dose antimicrobial prophylaxis is as effective as a 48-h regimen. Targeting high-risk groups is effective.</p>\",\"PeriodicalId\":22494,\"journal\":{\"name\":\"The Australian and New Zealand journal of surgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1046/j.1440-1622.2000.01837.x\",\"citationCount\":\"50\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Australian and New Zealand journal of surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1046/j.1440-1622.2000.01837.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Australian and New Zealand journal of surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1046/j.1440-1622.2000.01837.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Single-versus multiple-dose antibiotics prophylaxis for cardiac surgery.
Background: This study was carried out to determine if single-dose antimicrobial prophylaxis is sufficient for cardiac surgery.
Methods: The study was a prospective non-randomized trial of 353 consecutive patients undergoing cardiac surgery. Group A (n = 151) received 48 h of prophylaxis and Group B (n = 202) received a single dose. Cephazolin was used in all patients except those at high risk from methicillin-resistant Staphylococcus aureus (MRSA) who received teicoplanin and timentin.
Results: There was an overall in-hospital infection rate of 2.8%. There was no significant difference in rate or type of infection between the two groups.
Conclusions: An in-hospital infection rate of 2.8% compares favourably with other reported series. Single-dose antimicrobial prophylaxis is as effective as a 48-h regimen. Targeting high-risk groups is effective.
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