Lucy S.K Walker , Adam Gulbranson-Judge , Sarah Flynn , Thomas Brocker , Peter J.L Lane
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Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40
Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.
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