{"title":"中度和重度营养不良大鼠的身体生长和食物摄入。","authors":"A B Orden, M C Muñe, H M Pucciarelli","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A longitudinal study with eighty-six rats (Rattus norvegicus albinus var. Wistar) of both sexes was made. The aim was to express adaptability to malnutrition in terms of Age-of-Fitness Point (AFP) and Trend-to-Fitness Stage (TFS). The AFP means the age in which both control and malnourished animals show the same Relative Food Intake (RFI) value, expressed in mg of food intake per g of body weight. The TFS means the percent of RFI reached by the malnourished animals at a given age stage. A TFS=70 for example, means that the animals have to gain 30% of RFI to reach its AFP. Growing animals were submitted to one of the following treatments: control (fed on a stock diet ad libitum), moderate malnutrition (fed on 1/2 of the daily stock diet of a control of the same age and sex) and severe malnutrition (fed on 1/3 of the mentioned diet). Body weight and food intake of all of the animals were registered every ten days, when they were from 20 to 80 days old. Relative Food Intake (RFI) was calculated dividing the food intake (mg) of each animal/day by its respective body weight (g). The RFI data series belonging to each sex and treatment was obtained. The significance of the three independent variables (age, sex, and nutrition) was tested by multiple regressions. Covariation and degree of linearity between RFI and age were tested by simple correlation and simple regression tests. The intercepts of the regressions were all significant. For both sexes they were greater in controls than in the moderately malnourished group, in the latter being greater than in the severely malnourished group. The slopes were significant and negative in all of the groups. While, in males and females, control and moderately malnourished rats showed little differences, the severely malnourished slopes were, respectively, 3.2 and 2.4 times lower than in controls. In controls there were sexual differences for RFI correlated with age which were not present in the malnourished groups. The AFP was calculated by extrapolation: 80-90 days of age in males, with RFI of 80 mg/g, and 100-110 days of age in females, with RFI of 70 mg/g. In males TFS was 29.5% and 88.6 % in moderate and severe malnutrition, respectively. In females these values were 9.1% and 63.2%, respectively. Sexual dimorphism in TFS was significant in the moderately malnourished animals and nonsignificant in the severely malnourished ones.</p>","PeriodicalId":55080,"journal":{"name":"Growth Development and Aging","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Body growth and food intake in moderately and severely malnourished rats.\",\"authors\":\"A B Orden, M C Muñe, H M Pucciarelli\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A longitudinal study with eighty-six rats (Rattus norvegicus albinus var. Wistar) of both sexes was made. The aim was to express adaptability to malnutrition in terms of Age-of-Fitness Point (AFP) and Trend-to-Fitness Stage (TFS). The AFP means the age in which both control and malnourished animals show the same Relative Food Intake (RFI) value, expressed in mg of food intake per g of body weight. The TFS means the percent of RFI reached by the malnourished animals at a given age stage. A TFS=70 for example, means that the animals have to gain 30% of RFI to reach its AFP. Growing animals were submitted to one of the following treatments: control (fed on a stock diet ad libitum), moderate malnutrition (fed on 1/2 of the daily stock diet of a control of the same age and sex) and severe malnutrition (fed on 1/3 of the mentioned diet). Body weight and food intake of all of the animals were registered every ten days, when they were from 20 to 80 days old. Relative Food Intake (RFI) was calculated dividing the food intake (mg) of each animal/day by its respective body weight (g). The RFI data series belonging to each sex and treatment was obtained. The significance of the three independent variables (age, sex, and nutrition) was tested by multiple regressions. Covariation and degree of linearity between RFI and age were tested by simple correlation and simple regression tests. The intercepts of the regressions were all significant. For both sexes they were greater in controls than in the moderately malnourished group, in the latter being greater than in the severely malnourished group. The slopes were significant and negative in all of the groups. While, in males and females, control and moderately malnourished rats showed little differences, the severely malnourished slopes were, respectively, 3.2 and 2.4 times lower than in controls. In controls there were sexual differences for RFI correlated with age which were not present in the malnourished groups. The AFP was calculated by extrapolation: 80-90 days of age in males, with RFI of 80 mg/g, and 100-110 days of age in females, with RFI of 70 mg/g. In males TFS was 29.5% and 88.6 % in moderate and severe malnutrition, respectively. In females these values were 9.1% and 63.2%, respectively. Sexual dimorphism in TFS was significant in the moderately malnourished animals and nonsignificant in the severely malnourished ones.</p>\",\"PeriodicalId\":55080,\"journal\":{\"name\":\"Growth Development and Aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Development and Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Development and Aging","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
对褐家鼠(Rattus norvegicus albinus var. Wistar) 86只进行了纵向研究。目的是用适能年龄点(AFP)和适能趋势阶段(TFS)来表达对营养不良的适应性。AFP指的是对照组动物和营养不良动物表现出相同的相对食物摄入量(RFI)值的年龄,RFI值以每克体重摄入的食物毫克数表示。TFS是指营养不良的动物在特定年龄阶段达到RFI的百分比。例如,TFS=70意味着动物必须获得30%的RFI才能达到AFP。将生长动物分为三组:对照组(随意饲喂母猪日粮)、中度营养不良组(饲喂同年龄、性别对照组日粮的1/2)和重度营养不良组(饲喂上述日粮的1/3)。从20 ~ 80日龄开始,每10天记录一次体重和摄食量。计算相对摄食量(RFI),用每只动物每天的摄食量(mg)除以其各自的体重(g),得到各性别、各处理的相对摄食量数据序列。通过多元回归检验三个自变量(年龄、性别、营养)的显著性。通过简单相关检验和简单回归检验RFI与年龄之间的共变和线性程度。回归的截距都是显著的。对于两性来说,对照组的这一比例都高于中度营养不良组,而中度营养不良组的这一比例高于重度营养不良组。所有组的斜率均显著为负。而在雄性和雌性中,对照组和中度营养不良大鼠差异不大,严重营养不良大鼠的坡度分别比对照组低3.2倍和2.4倍。在对照组中,RFI与年龄相关的性别差异在营养不良组中不存在。AFP由外推法计算:雄性80-90日龄,RFI为80 mg/g;雌性100-110日龄,RFI为70 mg/g。中度和重度营养不良的男性TFS分别为29.5%和88.6%。在女性中,这些值分别为9.1%和63.2%。性别二态性在中度营养不良动物中显著,在重度营养不良动物中不显著。
Body growth and food intake in moderately and severely malnourished rats.
A longitudinal study with eighty-six rats (Rattus norvegicus albinus var. Wistar) of both sexes was made. The aim was to express adaptability to malnutrition in terms of Age-of-Fitness Point (AFP) and Trend-to-Fitness Stage (TFS). The AFP means the age in which both control and malnourished animals show the same Relative Food Intake (RFI) value, expressed in mg of food intake per g of body weight. The TFS means the percent of RFI reached by the malnourished animals at a given age stage. A TFS=70 for example, means that the animals have to gain 30% of RFI to reach its AFP. Growing animals were submitted to one of the following treatments: control (fed on a stock diet ad libitum), moderate malnutrition (fed on 1/2 of the daily stock diet of a control of the same age and sex) and severe malnutrition (fed on 1/3 of the mentioned diet). Body weight and food intake of all of the animals were registered every ten days, when they were from 20 to 80 days old. Relative Food Intake (RFI) was calculated dividing the food intake (mg) of each animal/day by its respective body weight (g). The RFI data series belonging to each sex and treatment was obtained. The significance of the three independent variables (age, sex, and nutrition) was tested by multiple regressions. Covariation and degree of linearity between RFI and age were tested by simple correlation and simple regression tests. The intercepts of the regressions were all significant. For both sexes they were greater in controls than in the moderately malnourished group, in the latter being greater than in the severely malnourished group. The slopes were significant and negative in all of the groups. While, in males and females, control and moderately malnourished rats showed little differences, the severely malnourished slopes were, respectively, 3.2 and 2.4 times lower than in controls. In controls there were sexual differences for RFI correlated with age which were not present in the malnourished groups. The AFP was calculated by extrapolation: 80-90 days of age in males, with RFI of 80 mg/g, and 100-110 days of age in females, with RFI of 70 mg/g. In males TFS was 29.5% and 88.6 % in moderate and severe malnutrition, respectively. In females these values were 9.1% and 63.2%, respectively. Sexual dimorphism in TFS was significant in the moderately malnourished animals and nonsignificant in the severely malnourished ones.