α - l -聚焦酶在预测结直肠癌患者肿瘤复发高危人群中的作用。

Cancer detection and prevention Pub Date : 2000-01-01
J Fernández-Rodríguez, D Ayude, M P de la Cadena, V S Martínez-Zorzano, A de Carlos, A Caride-Castro, G de Castro, F J Rodríguez-Berrocal
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引用次数: 0

摘要

本研究的目的是研究α - l -聚焦酶的预后价值,以确定它是否有助于早期识别肿瘤复发高风险的结直肠癌病例。本文对123例经根治性手术治疗的大肠癌患者进行了研究。用荧光法测定每个患者肿瘤和正常粘膜中的α - l -聚焦酶活性。其他7个临床和病理特征也进行了研究。为了评估每个变量对无病期的影响,对患者进行了术后30个月的随访,并进行了统计生存分析。当α - l -聚焦酶活性相对下降大于52%时,复发率较高(log-rank检验,P = 0.0261)。本研究结果表明- l -聚焦酶活性可能是结直肠癌肿瘤复发的一个良好的独立预后因素。
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Alpha-L-fucosidase enzyme in the prediction of colorectal cancer patients at high risk of tumor recurrence.

The aim of this study was to examine the prognostic value of the alpha-L-fucosidase enzyme to determine whether it can help in the early recognition of colorectal cancer cases at high risk of tumor recurrence. One hundred and twenty-three colorectal carcinoma patients treated by curative surgery were studied. The alpha-L-fucosidase activity was assayed in the tumor and in normal mucosa from each patient using a fluorometric method. Seven other clinical and pathologic features were also studied. To evaluate the impact of each variable over the disease-free interval, a postoperative 30-month follow-up of patients was performed, and a statistical survival analysis was carried out. The recurrence appearance was higher when the relative decrease of alpha-L-fucosidase activity was more than 52% (log-rank test, P = .0261). The results of this work indicate that alpha-L-fucosidase activity appears to be a good independent prognostic factor of tumoral recurrence in colorectal carcinoma.

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