比利时人乳头瘤病毒在食管鳞状细胞癌中的作用评价。

IF 1.5 4区医学 Q2 Medicine Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01

M A Lambot, J Haot, M O Peny, I Fayt, J C Noël

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引用次数: 0

摘要

目的:探讨人乳头瘤病毒(HPV)在比利时食管鳞状细胞癌(OSCC)发病中的作用。方法:采用L1一致引物MY09-MY11对21例福尔马林固定和石蜡包埋的食管鳞状细胞癌进行HPV DNA pcr扩增，检测HPV感染的频率，该引物可识别约40种不同的HPV类型。19例OSCC手术边缘组织学正常的上皮样本和5例尸检中正常食管样本作为阴性对照。结果:21例OSCC中仅发现1例HPV阳性肿瘤(4.8%)。所有正常上皮对照均为阴性。结论:我们的数据与先前发表的数据一致，提示HPV感染在西欧国家食管鳞状细胞癌的发病机制中仅起次要作用。

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Evaluation of the role of human papillomavirus in oesophageal squamous cell carcinoma in Belgium.

Objective: To evaluate the putative role of human papillomavirus (HPV) in the aetiology of oesophageal squamous cell carcinoma (OSCC) in Belgium.

Methods: The frequency of HPV infection was determined using HPV DNA PCRamplification with L1 consensus primers MY09-MY11, able to recognise about 40 different HPV types, on twenty-one formalin-fixed and paraffin-embedded oesophageal squamous cells carcinomas. Nineteen samples of histologically normal epithelium from the surgical margins of the OSCC specimens and five samples from normal oesophagus obtained at autopsy served as negative controls.

Results: We found only one HPV positive tumour (4.8%) out of the 21 OSCC cases. All the normal epithelium controls remained negative.

Conclusions: Our data are in agreement with those previously published, suggesting that HPV infection only plays a minor role in the pathogenesis of oesophageal squamous cells carcinoma in West-European countries.

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来源期刊

Acta Gastro-Enterologica Belgica 医学-胃肠肝病学

CiteScore

2.80

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.