滤光工艺性能变化:取决于滤光片的批次、处理中心还是计数技术?

Neil Beckman, Jerard Seghatchian
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引用次数: 4

摘要

这项回顾性研究的目的是确定白细胞减少产品中所列举的白细胞污染的变化是由过滤器批次、处理中心还是计数技术相关问题引起的。还考虑了供体变异的影响。结果表明,对于某些红细胞过程,变异主要是计数技术差异的结果。其他产品没有显示出类似的趋势,尽管由于供体相关问题,所有的白细胞消耗过程可能会出现罕见的高白细胞计数失败,但不能排除有缺陷的过滤器批次,需要持续审查。
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Leucodepletion process performance variation: is it dependent on the batch of filters, the processing centre or the counting technology?

The aim of this retrospective study was to determine whether variations in the enumerated white cell contamination of leucocyte-depleted products was caused by the filter batch, the processing centre or by counting technology related issues. The influence of donor variation is also considered. The results suggest that for some red cell processes, variation is mainly the result of counting technology differences. Other products do not display similar trends though all leucodepletion processes may give rare high white count failures due to donor related issues, though defective filter batch cannot be excluded requiring continual review.

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