从结构到功能:方法和限制。

Nature Structural Biology Pub Date : 2000-11-01 DOI:10.1038/80784

J M Thornton, A E Todd, D Milburn, N Borkakoti, C A Orengo

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引用次数: 205

摘要

本文综述了目前从蛋白质及其复合物的结构数据中提取功能信息的方法。虽然结构同系物可能揭示可能的生化功能(可能隐藏在序列水平上)，但阐明蛋白质在体内的确切生物学作用只能通过包括其他结果，如表达和定位数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From structure to function: approaches and limitations.

This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a protein in vivo will only be possible by including other results, such as data on expression and localization.

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Nature Structural Biology

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