{"title":"含itam的跨膜接头DAP12在淋巴细胞和髓细胞功能中的作用","authors":"Lewis L Lanier, Alexander B.H Bakker","doi":"10.1016/S0167-5699(00)01745-X","DOIUrl":null,"url":null,"abstract":"<div><p>DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12<sup>−/−</sup>) show normal development of hematopoietic cells. However, DAP12<sup>−/−</sup> humans develop presenile dementia and bone cysts, and DAP12<sup>−/−</sup> mice show impaired immune responses<em>.</em></p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 611-614"},"PeriodicalIF":0.0000,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01745-X","citationCount":"215","resultStr":"{\"title\":\"The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function\",\"authors\":\"Lewis L Lanier, Alexander B.H Bakker\",\"doi\":\"10.1016/S0167-5699(00)01745-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12<sup>−/−</sup>) show normal development of hematopoietic cells. However, DAP12<sup>−/−</sup> humans develop presenile dementia and bone cysts, and DAP12<sup>−/−</sup> mice show impaired immune responses<em>.</em></p></div>\",\"PeriodicalId\":73346,\"journal\":{\"name\":\"Immunology today\",\"volume\":\"21 12\",\"pages\":\"Pages 611-614\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01745-X\",\"citationCount\":\"215\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunology today\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S016756990001745X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016756990001745X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12−/−) show normal development of hematopoietic cells. However, DAP12−/− humans develop presenile dementia and bone cysts, and DAP12−/− mice show impaired immune responses.
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