{"title":"非胰岛素依赖型糖尿病大鼠(OLETF)主动脉和肾动脉内皮依赖性反应性的改变","authors":"Satomi Kagota, Yu Yamaguchi, Kazuki Nakamura, Masaru Kunitomo","doi":"10.1016/S0306-3623(00)00061-6","DOIUrl":null,"url":null,"abstract":"<div><p>We examined endothelium-dependent relaxation in the aortas and renal arteries of Otsuka Long–Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus, in comparison with non-diabetic Long–Evans Tokushima Otsuka rats as controls. Acetylcholine-induced relaxation in both arteries was attenuated, and the attenuation was restored to the control level by indomethacin. The relaxation was inhibited completely in the aortas, but only partially in renal arteries by <em>N</em><sup>G</sup>-nitro-<span>l</span>-arginine methyl ester, and the degree of the latter inhibition was greater in OLETF rats than in the controls. The relaxation was inhibited by aminoguanidine in both arteries of OLETF rats but not in the controls. Serum NO<sub>2</sub> plus NO<sub>3</sub> levels significantly increased in OLETF rats. These results suggest that impairment of relaxation in OLETF rat arteries is due to increased release of contractile factors but not decreased release of nitric oxide.</p></div>","PeriodicalId":12607,"journal":{"name":"General Pharmacology-the Vascular System","volume":"34 3","pages":"Pages 201-209"},"PeriodicalIF":0.0000,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0306-3623(00)00061-6","citationCount":"53","resultStr":"{\"title\":\"Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long–Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus\",\"authors\":\"Satomi Kagota, Yu Yamaguchi, Kazuki Nakamura, Masaru Kunitomo\",\"doi\":\"10.1016/S0306-3623(00)00061-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We examined endothelium-dependent relaxation in the aortas and renal arteries of Otsuka Long–Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus, in comparison with non-diabetic Long–Evans Tokushima Otsuka rats as controls. Acetylcholine-induced relaxation in both arteries was attenuated, and the attenuation was restored to the control level by indomethacin. The relaxation was inhibited completely in the aortas, but only partially in renal arteries by <em>N</em><sup>G</sup>-nitro-<span>l</span>-arginine methyl ester, and the degree of the latter inhibition was greater in OLETF rats than in the controls. The relaxation was inhibited by aminoguanidine in both arteries of OLETF rats but not in the controls. Serum NO<sub>2</sub> plus NO<sub>3</sub> levels significantly increased in OLETF rats. These results suggest that impairment of relaxation in OLETF rat arteries is due to increased release of contractile factors but not decreased release of nitric oxide.</p></div>\",\"PeriodicalId\":12607,\"journal\":{\"name\":\"General Pharmacology-the Vascular System\",\"volume\":\"34 3\",\"pages\":\"Pages 201-209\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0306-3623(00)00061-6\",\"citationCount\":\"53\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"General Pharmacology-the Vascular System\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306362300000616\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"General Pharmacology-the Vascular System","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306362300000616","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long–Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus
We examined endothelium-dependent relaxation in the aortas and renal arteries of Otsuka Long–Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus, in comparison with non-diabetic Long–Evans Tokushima Otsuka rats as controls. Acetylcholine-induced relaxation in both arteries was attenuated, and the attenuation was restored to the control level by indomethacin. The relaxation was inhibited completely in the aortas, but only partially in renal arteries by NG-nitro-l-arginine methyl ester, and the degree of the latter inhibition was greater in OLETF rats than in the controls. The relaxation was inhibited by aminoguanidine in both arteries of OLETF rats but not in the controls. Serum NO2 plus NO3 levels significantly increased in OLETF rats. These results suggest that impairment of relaxation in OLETF rat arteries is due to increased release of contractile factors but not decreased release of nitric oxide.
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