{"title":"【第二次骨折愈合过程中ⅰ型和ⅱ型胶原蛋白的表达】。","authors":"Xian Zhang, Fan Wang, Hongmei Jiang, Ruixiang Li","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to disclose the rules of collagen type I and II production and hence to acquire knowledge about the mechanism of repairing during the second period of fracture healing.</p><p><strong>Methods: </strong>An experimental model of second fracture healing at rat's femurs was used to study the production of collagen type I and II by means of immunohistochemistry; meanwhile the histologic changes were observed with the use of HE staining and Alcian blue staining at 3 days, 1, 2, 3, 4 weeks postoperatively.</p><p><strong>Results: </strong>The expression of both collagen type I and II was detected by immunohistochemistry at 1 week. The peak expression of collagen type II occurred at 3 weeks. The higher expression of collagen type I was observed at 4 weeks.</p><p><strong>Conclusion: </strong>The morphologic changes of chondrocyte and the production of collagen type I and II by chondrocyte in cartilage callus are correlated with their repairing function during different periods of fracture healing.</p>","PeriodicalId":13173,"journal":{"name":"Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao","volume":"33 2","pages":"204-6"},"PeriodicalIF":0.0000,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The expression of collagen type I and type II during the second fracture healing].\",\"authors\":\"Xian Zhang, Fan Wang, Hongmei Jiang, Ruixiang Li\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study was conducted to disclose the rules of collagen type I and II production and hence to acquire knowledge about the mechanism of repairing during the second period of fracture healing.</p><p><strong>Methods: </strong>An experimental model of second fracture healing at rat's femurs was used to study the production of collagen type I and II by means of immunohistochemistry; meanwhile the histologic changes were observed with the use of HE staining and Alcian blue staining at 3 days, 1, 2, 3, 4 weeks postoperatively.</p><p><strong>Results: </strong>The expression of both collagen type I and II was detected by immunohistochemistry at 1 week. The peak expression of collagen type II occurred at 3 weeks. The higher expression of collagen type I was observed at 4 weeks.</p><p><strong>Conclusion: </strong>The morphologic changes of chondrocyte and the production of collagen type I and II by chondrocyte in cartilage callus are correlated with their repairing function during different periods of fracture healing.</p>\",\"PeriodicalId\":13173,\"journal\":{\"name\":\"Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao\",\"volume\":\"33 2\",\"pages\":\"204-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[The expression of collagen type I and type II during the second fracture healing].
Objective: This study was conducted to disclose the rules of collagen type I and II production and hence to acquire knowledge about the mechanism of repairing during the second period of fracture healing.
Methods: An experimental model of second fracture healing at rat's femurs was used to study the production of collagen type I and II by means of immunohistochemistry; meanwhile the histologic changes were observed with the use of HE staining and Alcian blue staining at 3 days, 1, 2, 3, 4 weeks postoperatively.
Results: The expression of both collagen type I and II was detected by immunohistochemistry at 1 week. The peak expression of collagen type II occurred at 3 weeks. The higher expression of collagen type I was observed at 4 weeks.
Conclusion: The morphologic changes of chondrocyte and the production of collagen type I and II by chondrocyte in cartilage callus are correlated with their repairing function during different periods of fracture healing.
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