{"title":"磷脂酶A2","authors":"Bruno L. Diaz , Jonathan P. Arm","doi":"10.1016/S0952-3278(03)00069-3","DOIUrl":null,"url":null,"abstract":"<div><div><span><span>Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of </span>eicosanoids<span><span>, lipid<span> mediators derived from arachidonic acid, such as </span></span>prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A</span></span><sub>2</sub><span> enzymes in providing arachidonic acid to the downstream enzymes for eicosanoid generation in biologic processes has not been fully elucidated. In this review, we will provide an overview of the classification of the families of PLA</span><sub>2</sub> enzymes, their putative mechanisms of action, and their role(s) in eicosanoid generation and inflammation.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"69 2","pages":"Pages 87-97"},"PeriodicalIF":3.2000,"publicationDate":"2003-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phospholipase A2\",\"authors\":\"Bruno L. Diaz , Jonathan P. Arm\",\"doi\":\"10.1016/S0952-3278(03)00069-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><span><span>Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of </span>eicosanoids<span><span>, lipid<span> mediators derived from arachidonic acid, such as </span></span>prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A</span></span><sub>2</sub><span> enzymes in providing arachidonic acid to the downstream enzymes for eicosanoid generation in biologic processes has not been fully elucidated. In this review, we will provide an overview of the classification of the families of PLA</span><sub>2</sub> enzymes, their putative mechanisms of action, and their role(s) in eicosanoid generation and inflammation.</div></div>\",\"PeriodicalId\":94179,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"volume\":\"69 2\",\"pages\":\"Pages 87-97\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2003-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0952327803000693\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2003/7/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952327803000693","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2003/7/26 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of eicosanoids, lipid mediators derived from arachidonic acid, such as prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A2 enzymes in providing arachidonic acid to the downstream enzymes for eicosanoid generation in biologic processes has not been fully elucidated. In this review, we will provide an overview of the classification of the families of PLA2 enzymes, their putative mechanisms of action, and their role(s) in eicosanoid generation and inflammation.
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