格列美脲-b-环糊精配合物的研究。

Bollettino chimico farmaceutico Pub Date : 2003-11-01

J R Moyano, T Ventriglia, J M Ginés, F Muñoz, A M Rabasco

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引用次数: 0

摘要

采用核磁共振(1H NMR)、红外光谱(FTIR)、粉末x射线衍射(XRD)、热分析(DSC)和扫描电镜(SEM)等分析技术研究了格列美脲与b-环糊精(b-CD)的相互作用。通过相溶解度技术和1H NMR证明了包合物在溶液中的存在，通过DSC、FTIR和XRD证明了包合物在固体中的存在，并通过密封加热和冷冻干燥分离。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Study of glimepiride-b-cyclodextrin complex.

The interaction of glimepiride with b-cyclodextrin (b-CD) has been studied by several analytical techniques, including 1H NMR, infrared spectroscopy (FTIR), powder x-ray diffractometry (XRD), thermal analysis (DSC) and scanning electron microscopy (SEM). The existence of an inclusion complex was proved in solution by phase solubility techniques and 1H NMR, and in the solid state by DSC, FTIR and XRD, being isolated by sealed heating and freeze drying procedures.

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Bollettino chimico farmaceutico

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