褪黑素暴露报告在1998-2003年的德克萨斯州中毒中心。

Veterinary and human toxicology Pub Date : 2004-12-01
Mathias B Forrester
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引用次数: 0

摘要

褪黑激素调节昼夜节律,尽管在美国广泛使用,但关于公众使用褪黑激素以及与该物质相关的不良反应模式的信息有限。为了描述1998-2003年期间向德克萨斯州中毒中心报告的褪黑素电话的模式,分析了向德克萨斯州中毒中心网络报告的所有褪黑素电话的数据。在1998-2003年间,有779人暴露于褪黑素。在已知年龄的患者中,59.1%的患者小于6岁。男性占学龄前患者的54.1%,而老年患者中更多的是女性。在6岁以下儿童中,99.3%的褪黑素暴露是无意的,而在年龄较大的年龄组中,这一比例低于41%。虽然92.4%涉及最年轻年龄组的暴露是在卫生保健机构外处理的,但发生在6岁以上患者的暴露中有42%或更少是在卫生保健机构外处理的。在已知结果的病例中,至少有轻微影响的病例比例随着年龄的增长而上升。向德克萨斯州中毒中心报告的大多数褪黑素暴露涉及小于6岁的儿童。年轻的患者更可能是男性,无意暴露,没有临床效果,不需要在卫生保健机构进行管理。观察到的临床效果及治疗方法与文献一致。
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Melatonin exposures reported to Texas poison centers in 1998-2003.

Melatonin regulates circadian rhythms, and although widely used in the US, information on the public use of melatonin and patterns of reported adverse effects associated with the substance is limited. To describe the patterns of melatonin calls to poison centers in Texas during 1998-2003, data on all melatonin calls reported to the Texas Poison Center Network were analyzed. During 1998-2003, there were 779 identified human exposures to melatonin identified. Of those patients with a known age, 59.1% were < 6 y. Males accounted for 54.1% of preschool-age patients while more of the older patients were female. Melatonin exposures were unintentional in 99.3% of the cases among children less than 6y and unintentional in < 41% among the older age groups. While 92.4% of exposures involving theyoungest age group were managed outside of a health care facility, 42% or less of the exposures occurring to patients > age 6 years were managed outside of a health care facility. Of those cases with a known outcome, the proportion of cases with at least minor effects rose with increasing age. The majority of melatonin exposures reported to Texas poison centers involved children < 6 y. Younger patients were more likely to be male, have unintentional exposures, have no clinical effect, and to not require management at health care facilities. The observed clinical effects and treatment methods were consistent with the literature.

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