吐酒石治疗酒精滥用的锑毒性。

Veterinary and human toxicology Pub Date : 2004-12-01
Asim F Tarabar, Yasmin Khan, Lewis S Nelson, Robert S Hoffman
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引用次数: 0

摘要

锑是一种有毒元素,具有类似砷的毒性。许多报告描述了与锑接触有关的呕吐、腹泻和口炎等胃肠道并发症。然而,使用吐酒石治疗酗酒所产生的锑毒性,以前从未有过报道。一名有酗酒史的19岁男子服用了危地马拉为治疗酗酒而生产的一瓶10毫升"至关重要"(吐酒石,50毫克/毫升)。患者在摄入后60分钟出现严重呕吐、腹部痉挛、腹泻、虚弱和直立。最初的实验室评估显示肌酐为2.5 mg/dL,钾为6.1 mEq/L,红细胞压积为60%。给他注射了活性炭、生理盐水和止吐药。在接下来的48小时内,他的肌酐恢复到1.1 mg/dL,红细胞压积恢复到53%;尿锑浓度1200 mcg/L(正常= < 10 mcg/L)。重要的是要认识到,可以使用除双硫仑以外的外国酒精疗法,这种外国产品的成分应加以确定。
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Antimony toxicity from the use of tartar emetic for the treatment of alcohol abuse.

Antimony is a poisonous element with toxic properties that mimic those of arsenic. Numerous reports describe gastrointestinal complications of vomiting, diarrhea and stomatitis associated with antimony exposure. However, antimony toxicity from the use of tartar emetic as a treatment for alcohol abuse has never been described previously. A 19-y-o man with a history of alcohol abuse ingested a 10 mL bottle of "Soluto Vital" (tartar emetic, 50 mg/mL), produced in Guatemala for treatment of alcohol abuse. He presented 60 min after ingestion with severe vomiting, abdominal cramps, diarrhea, weakness and orthostasis. Initial laboratory evaluations were remarkable for creatinine of 2.5 mg/dL, potassium 6.1 mEq/L, and 60% hematocrit. He was given activated charcoal, iv saline and antiemetics. Over the next 48 h his creatinine normalized to 1.1 mg/dL and the hematocrit returned to 53%; urine had an antimony concentration of 1200 mcg/L (normal = < 10 mcg/L). It is important to recognize that foreign alcohol therapies aversive therapy other than disulfiram may be used, the contents of such a foreign product should be identified.

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