[胰岛素抵抗和高胰岛素血症——青春期人群代谢综合征的危险因素]。

Ewa Otto Buczkowska
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引用次数: 0

摘要

青春期胰岛素抵抗已被充分证明,青春期胰岛素敏感性(Sl)的下降与胰岛素分泌的代偿性增加有关。对青春期胰岛素抵抗的观察表明,在坦纳期II-IV期的儿童样本中,胰岛素刺激的葡萄糖代谢比坦纳期I期的儿童或成人低约30%。虽然青春期胰岛素抵抗的现象有很好的文献记载,但其机制尚未明确确定。青春期胰岛素抵抗发生在身体成分和激素水平发生深刻变化的时期。机体对胰岛素作用的抵抗导致胰腺分泌这种激素的增加,从而导致高胰岛素血症。儿童期开始的肥胖往往先于高胰岛素状态。胰岛素抵抗综合征的其他组成部分也存在于儿童和青少年中。胰岛素抵抗、高胰岛素血症、血脂异常、高血压和肥胖,特别是在星座,是青少年和年轻人冠状动脉粥样硬化的潜在危险因素。早期饮食、运动和行为治疗的保守干预可以预防胰岛素抵抗的并发症。
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[Insulin resistance and hyperinsulinemia--risk factors of the metabolic syndrome in the pubertal population].

Pubertal insulin resistance has been well documented, the fall in insulin sensitivity (Sl) during puberty is associated with a compensatory increase in insulin secretion. Observation of pubertal insulin resistance showed that insulin-stimulated glucose metabolism was approximately 30% lower in a sample of children at Tanner stages II-IV compared with children at Tanner stage I or adults. Although the phenomenon of pubertal insulin resistance is well documented, the mechanism has not been clearly determined. Pubertal insulin resistance occurs during a time of profound changes in body composition and hormone levels. Resistance of the body to the actions of insulin results in increased production of this hormone by the pancreas and ensuing hyperinsulinemia. Obesity beginning in childhood often precedes the hyperinsulinemic state. Other components of the insulin resistance syndrome are also present in children and adolescents. Conditions of insulin resistance, hyperinsulinemia, dyslipidemia, hypertension and obesity, especially in constellation, are potent risk factors of coronary atherosclerosis among adolescents and young adults. Early conservative intervention with diet, exercise, and behavioral therapy may prevent the complications of insulin resistance.

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