Andrei A. Bunaciu , Hassan Y. Aboul-Enein , Şerban Fleschin
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Quantitative analysis of bucillamine and its pharmaceutical formulation using FT-IR spectroscopy
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of bucillamine. Conventional KBr-spectra and DRIFTS spectra were compared for best determination of active substance in its tablet formulation. Two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods were used in data processing. Similar results were obtained with both chemometric methods.
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