{"title":"以2-重氮- 1,2 -二芳基乙醇和N-(2-噻吩)亚胺为原料合成2-叠氮二酮作为可能的抗菌剂","authors":"Girija S. Singh, Boycie J. Mmolotsi","doi":"10.1016/j.farmac.2005.06.008","DOIUrl":null,"url":null,"abstract":"<div><p>An equimolar reaction of 2-diazo-1, 2-diarylethanones with <em>N</em>-(2-thienylidene)imines affords 1-substituted-3, 3-diaryl-4-(2-thienyl)-2-azetidinones in excellent yields. The products have been characterized on the basis of satisfactory analytical and spectral (IR, <sup>1</sup>H and <sup>13</sup>C NMR, MS) data. The mechanism of formation of the products is shown. The antimicrobial activity of the compounds against some Gram(+) and Gram(–) bacteria, and fungi is reported.</p></div>","PeriodicalId":77128,"journal":{"name":"Farmaco (Societa chimica italiana : 1989)","volume":"60 9","pages":"Pages 727-730"},"PeriodicalIF":0.0000,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmac.2005.06.008","citationCount":"35","resultStr":"{\"title\":\"Synthesis of 2-azetidinones from 2-diazo-1, 2-diarylethanones and N-(2-thienylidene)imines as possible antimicrobial agents\",\"authors\":\"Girija S. Singh, Boycie J. Mmolotsi\",\"doi\":\"10.1016/j.farmac.2005.06.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>An equimolar reaction of 2-diazo-1, 2-diarylethanones with <em>N</em>-(2-thienylidene)imines affords 1-substituted-3, 3-diaryl-4-(2-thienyl)-2-azetidinones in excellent yields. The products have been characterized on the basis of satisfactory analytical and spectral (IR, <sup>1</sup>H and <sup>13</sup>C NMR, MS) data. The mechanism of formation of the products is shown. The antimicrobial activity of the compounds against some Gram(+) and Gram(–) bacteria, and fungi is reported.</p></div>\",\"PeriodicalId\":77128,\"journal\":{\"name\":\"Farmaco (Societa chimica italiana : 1989)\",\"volume\":\"60 9\",\"pages\":\"Pages 727-730\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.farmac.2005.06.008\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Farmaco (Societa chimica italiana : 1989)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014827X05001369\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmaco (Societa chimica italiana : 1989)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014827X05001369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis of 2-azetidinones from 2-diazo-1, 2-diarylethanones and N-(2-thienylidene)imines as possible antimicrobial agents
An equimolar reaction of 2-diazo-1, 2-diarylethanones with N-(2-thienylidene)imines affords 1-substituted-3, 3-diaryl-4-(2-thienyl)-2-azetidinones in excellent yields. The products have been characterized on the basis of satisfactory analytical and spectral (IR, 1H and 13C NMR, MS) data. The mechanism of formation of the products is shown. The antimicrobial activity of the compounds against some Gram(+) and Gram(–) bacteria, and fungi is reported.
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