{"title":"对 F344/NTac 大鼠和 B6C3F1/N 小鼠经皮施用 5-amino-o-cresol 的毒性研究。","authors":"","doi":"10.22427/NTP-TOX-89","DOIUrl":null,"url":null,"abstract":"<p><p>5-Amino-o-cresol is used as an oxidative dye coupler (secondary intermediate) or oxidative (permanent) in hair dye formulations. It was nominated for study by the National Cancer Institute because it is a widely used genotoxic hair dye component for which no cancer studies have been reported. Male and female F344/NTac rats and B6C3F1/N mice were administered 5-amino-o-cresol (greater than 99% pure) dermally for 3 months. Genetic toxicology studies were conducted in Salmonella typhimurium, peripheral blood erythrocytes of male and female mice, and bone marrow of male mice. (Abstract Abridged).</p>","PeriodicalId":23116,"journal":{"name":"Toxicity report series","volume":" 89","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039873/pdf/","citationCount":"0","resultStr":"{\"title\":\"Toxicity studies of 5-amino-o-cresol administered dermally to F344/NTac rats and B6C3F1/N mice.\",\"authors\":\"\",\"doi\":\"10.22427/NTP-TOX-89\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>5-Amino-o-cresol is used as an oxidative dye coupler (secondary intermediate) or oxidative (permanent) in hair dye formulations. It was nominated for study by the National Cancer Institute because it is a widely used genotoxic hair dye component for which no cancer studies have been reported. Male and female F344/NTac rats and B6C3F1/N mice were administered 5-amino-o-cresol (greater than 99% pure) dermally for 3 months. Genetic toxicology studies were conducted in Salmonella typhimurium, peripheral blood erythrocytes of male and female mice, and bone marrow of male mice. (Abstract Abridged).</p>\",\"PeriodicalId\":23116,\"journal\":{\"name\":\"Toxicity report series\",\"volume\":\" 89\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039873/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicity report series\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22427/NTP-TOX-89\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicity report series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22427/NTP-TOX-89","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Toxicity studies of 5-amino-o-cresol administered dermally to F344/NTac rats and B6C3F1/N mice.
5-Amino-o-cresol is used as an oxidative dye coupler (secondary intermediate) or oxidative (permanent) in hair dye formulations. It was nominated for study by the National Cancer Institute because it is a widely used genotoxic hair dye component for which no cancer studies have been reported. Male and female F344/NTac rats and B6C3F1/N mice were administered 5-amino-o-cresol (greater than 99% pure) dermally for 3 months. Genetic toxicology studies were conducted in Salmonella typhimurium, peripheral blood erythrocytes of male and female mice, and bone marrow of male mice. (Abstract Abridged).
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