{"title":"隐孢子虫:宿主-寄生虫相互作用及其发病机制。","authors":"Derek J Pinto, Sumiti Vinayak","doi":"10.1007/s40588-021-00159-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong><i>Cryptosporidium</i> spp. (<i>C. hominis</i> and <i>C. parvum</i>) are a major cause of diarrhea-associated morbidity and mortality in young children globally. While <i>C. hominis</i> only infects humans, <i>C. parvum</i> is a zoonotic parasite that can be transmitted from infected animals to humans. There are no treatment or control measures to fully treat cryptosporidiosis or prevent the infection in humans and animals. Our knowledge on the molecular mechanisms of <i>Cryptosporidium</i>-host interactions and the underlying factors that govern infectivity and disease pathogenesis is very limited.</p><p><strong>Recent findings: </strong>Recent development of genetics and new animal models of infection, along with progress in cell culture platforms to complete the parasite lifecycle in vitro, is greatly advancing the <i>Cryptosporidium</i> field.</p><p><strong>Summary: </strong>In this review, we will discuss our current knowledge of host-parasite interactions and how genetic manipulation of <i>Cryptosporidium</i> and promising infection models are opening the doors towards an improved understanding of parasite biology and disease pathogenesis.</p>","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"8 2","pages":"62-67"},"PeriodicalIF":3.1000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-021-00159-7","citationCount":"23","resultStr":"{\"title\":\"<i>Cryptosporidium</i>: Host-Parasite Interactions and Pathogenesis.\",\"authors\":\"Derek J Pinto, Sumiti Vinayak\",\"doi\":\"10.1007/s40588-021-00159-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong><i>Cryptosporidium</i> spp. (<i>C. hominis</i> and <i>C. parvum</i>) are a major cause of diarrhea-associated morbidity and mortality in young children globally. While <i>C. hominis</i> only infects humans, <i>C. parvum</i> is a zoonotic parasite that can be transmitted from infected animals to humans. There are no treatment or control measures to fully treat cryptosporidiosis or prevent the infection in humans and animals. Our knowledge on the molecular mechanisms of <i>Cryptosporidium</i>-host interactions and the underlying factors that govern infectivity and disease pathogenesis is very limited.</p><p><strong>Recent findings: </strong>Recent development of genetics and new animal models of infection, along with progress in cell culture platforms to complete the parasite lifecycle in vitro, is greatly advancing the <i>Cryptosporidium</i> field.</p><p><strong>Summary: </strong>In this review, we will discuss our current knowledge of host-parasite interactions and how genetic manipulation of <i>Cryptosporidium</i> and promising infection models are opening the doors towards an improved understanding of parasite biology and disease pathogenesis.</p>\",\"PeriodicalId\":45506,\"journal\":{\"name\":\"Current Clinical Microbiology Reports\",\"volume\":\"8 2\",\"pages\":\"62-67\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s40588-021-00159-7\",\"citationCount\":\"23\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Clinical Microbiology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s40588-021-00159-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/2/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Clinical Microbiology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40588-021-00159-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/2/8 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Cryptosporidium: Host-Parasite Interactions and Pathogenesis.
Purpose of review: Cryptosporidium spp. (C. hominis and C. parvum) are a major cause of diarrhea-associated morbidity and mortality in young children globally. While C. hominis only infects humans, C. parvum is a zoonotic parasite that can be transmitted from infected animals to humans. There are no treatment or control measures to fully treat cryptosporidiosis or prevent the infection in humans and animals. Our knowledge on the molecular mechanisms of Cryptosporidium-host interactions and the underlying factors that govern infectivity and disease pathogenesis is very limited.
Recent findings: Recent development of genetics and new animal models of infection, along with progress in cell culture platforms to complete the parasite lifecycle in vitro, is greatly advancing the Cryptosporidium field.
Summary: In this review, we will discuss our current knowledge of host-parasite interactions and how genetic manipulation of Cryptosporidium and promising infection models are opening the doors towards an improved understanding of parasite biology and disease pathogenesis.
期刊介绍：
Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.
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