隐孢子虫:宿主-寄生虫相互作用及其发病机制。

IF 3.1 Q2 MICROBIOLOGY Current Clinical Microbiology Reports Pub Date : 2021-01-01 Epub Date: 2021-02-08 DOI:10.1007/s40588-021-00159-7
Derek J Pinto, Sumiti Vinayak
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引用次数: 23

摘要

综述目的:隐孢子虫(人隐孢子虫和细小隐孢子虫)是全球幼儿腹泻相关发病率和死亡率的主要原因。虽然人弓形虫只感染人类,但细小弓形虫是一种人畜共患寄生虫,可以从受感染的动物传播给人类。没有治疗或控制措施来充分治疗隐孢子虫病或预防人类和动物的感染。我们对隐孢子虫与宿主相互作用的分子机制以及控制感染性和疾病发病机制的潜在因素的了解非常有限。最新发现:最近遗传学和新的感染动物模型的发展,以及细胞培养平台在体外完成寄生虫生命周期的进展,极大地推动了隐孢子虫领域的发展。摘要:在这篇综述中,我们将讨论我们目前对宿主-寄生虫相互作用的了解,以及隐孢子虫的遗传操作和有希望的感染模型如何为提高对寄生虫生物学和疾病发病机制的理解打开大门。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Cryptosporidium: Host-Parasite Interactions and Pathogenesis.

Purpose of review: Cryptosporidium spp. (C. hominis and C. parvum) are a major cause of diarrhea-associated morbidity and mortality in young children globally. While C. hominis only infects humans, C. parvum is a zoonotic parasite that can be transmitted from infected animals to humans. There are no treatment or control measures to fully treat cryptosporidiosis or prevent the infection in humans and animals. Our knowledge on the molecular mechanisms of Cryptosporidium-host interactions and the underlying factors that govern infectivity and disease pathogenesis is very limited.

Recent findings: Recent development of genetics and new animal models of infection, along with progress in cell culture platforms to complete the parasite lifecycle in vitro, is greatly advancing the Cryptosporidium field.

Summary: In this review, we will discuss our current knowledge of host-parasite interactions and how genetic manipulation of Cryptosporidium and promising infection models are opening the doors towards an improved understanding of parasite biology and disease pathogenesis.

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来源期刊
CiteScore
7.50
自引率
1.90%
发文量
9
期刊介绍: Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.
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