IF 2 4区 医学Q3 MEDICINE, RESEARCH & EXPERIMENTALDiscovery medicinePub Date : 2020-11-01
Yin Liang, Jian He, Yongxiang Zhao
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Modification of oncolytic adenovirus and its application in cancer therapy.
Oncolytic virus refers to a type of virus that can replicate in tumor cells and eventually lyse them. Oncolytic adenoviruses are widely used because of their acceptable safety, but they are also limited in their clinical applications due to their own limitations. Therefore, the adenovirus is modified in multiple ways to improve the safety of the treatment, enhance the impact of oncolysis, and reduce the effect of neutralizing antibodies on the virus. The combined application of oncolytic adenovirus and other drugs plays a synergistic role in the treatment of tumors.
期刊介绍：
Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.
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