{"title":"新型小鼠模型拓展了潜在的人类α细胞研究。","authors":"Theodore Dos Santos, Patrick E MacDonald","doi":"10.1080/19382014.2021.1914507","DOIUrl":null,"url":null,"abstract":"<p><p>A glucagon knock-out mouse with preserved GLP-1 and GLP-2 secretion allows for the improved study of transplanted human islets and glucagon responses- providing an unprecedented resource in human α-cell and diabetes research.</p>","PeriodicalId":14671,"journal":{"name":"Islets","volume":"13 3-4","pages":"80-83"},"PeriodicalIF":1.9000,"publicationDate":"2021-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19382014.2021.1914507","citationCount":"0","resultStr":"{\"title\":\"Novel mouse model expands potential human α-cell research.\",\"authors\":\"Theodore Dos Santos, Patrick E MacDonald\",\"doi\":\"10.1080/19382014.2021.1914507\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A glucagon knock-out mouse with preserved GLP-1 and GLP-2 secretion allows for the improved study of transplanted human islets and glucagon responses- providing an unprecedented resource in human α-cell and diabetes research.</p>\",\"PeriodicalId\":14671,\"journal\":{\"name\":\"Islets\",\"volume\":\"13 3-4\",\"pages\":\"80-83\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2021-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/19382014.2021.1914507\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Islets\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/19382014.2021.1914507\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/4/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Islets","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/19382014.2021.1914507","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/4/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Novel mouse model expands potential human α-cell research.
A glucagon knock-out mouse with preserved GLP-1 and GLP-2 secretion allows for the improved study of transplanted human islets and glucagon responses- providing an unprecedented resource in human α-cell and diabetes research.
期刊介绍：
Islets is the first international, peer-reviewed research journal dedicated to islet biology. Islets publishes high-quality clinical and experimental research into the physiology and pathology of the islets of Langerhans. In addition to original research manuscripts, Islets is the leading source for cutting-edge Perspectives, Reviews and Commentaries.
Our goal is to foster communication and a rapid exchange of information through timely publication of important results using print as well as electronic formats.
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