【老年乳糜泻1例报告】。

Fiorenzo Baroni, Maria Karin Ghisla, Roberto Leonardi, Vittorio Grassi
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引用次数: 0

摘要

乳糜泻是老年人吸收不良的一个不可忽视的原因。腹泻、体重减轻和腹部不适通常不存在,因此乳糜泻在老年人中确实有一个微妙的、无症状的病程。50%以上患者有肠外症状;只有10-40%的患者有小肠活检的典型症状。从饮食中去除谷蛋白是治疗的基石。一位73岁女性因缺氧、体重减轻、抑郁、肠道异常和日常生活工具活动能力的进行性恶化而被转介到我科。有抗麦胶蛋白抗体和抗肌内膜抗体。随后对十二指肠第二和第三部分的小肠活检显示绒毛大部萎缩,上皮内淋巴细胞增加以及腺体增生(III型Marsh评分)。所有这些病理结果都符合乳糜泻的诊断因此无谷蛋白饮食开始了。
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[Celiac disease in the elderly: a case report].

Celiac disease is not a negligible cause of malabsorption in the elderly. Diarrhea, loss of weight and abdominal discomfort are often absent so that celiac disease has indeed a subtle, paucisymptomatic, course in the elderly. More than 50% of the patients have extraintestinal symptoms; only 10-40% have typical complaints pointing to small-intestinal biopsy. Elimination of gluten from diet is the cornerstone of the therapy. A 73-year-old woman with hyporexia, loss of weight, depression, bowel abnormalities and progressive deterioration of her abilities in the instrumental activities of daily living was referred to our department. Antigliadin and antiendomysial antibodies were present. A subsequent small-intestinal biopsy of the second and third portion of duodenum showed subtotal villous atrophy, increase of intra-epithelial lymphocytes as well as hyperplastic glands (type III Marsh score). All these pathological findings were compatible with celiac disease diagnosis so that a gluten-free diet was then initiated.

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