[儿童急性淋巴细胞白血病维持治疗期间和之后体重指数与瘦素水平的关系]。

Katarzyna Muszyńska-Rosłan, Maryna Krawczuk-Rybak, Magda Topczewska, Małgorzata Sawicka-Zukowska
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引用次数: 0

摘要

未标记:我们分析了急性淋巴细胞白血病患儿在维持治疗期间和之后的血清瘦素水平与体重指数之间的关系。材料和方法:我们研究了99名幸存者(62名男孩),平均年龄12.65岁+/-,根据波兰儿科白血病和淋巴瘤研究组,他们接受了ALL治疗。维持治疗期间n=34例(男孩23例),治疗后n=75例(男孩39例)。16例患者接受12 Gy颅脑照射。我们使用公式体重/(身高)2 (kg/m2)计算身体质量指数(BMI)。用RIA法测定瘦素水平。结果以SDS表示。结果:1。瘦素SDS和BMI SDS从零开始没有差异——在整个研究组中,男孩和女孩相似。女孩的瘦素/BMI比值明显高于男孩。2. 治疗期间和治疗后两组BMI SDS和瘦素SDS值均无差异。我们发现男孩在青春期(4.86+/-1.01)和青春期后(1.53+/-0.75)瘦素SDS较高。我们发现,在治疗期间(1.6+/-1.1 vs. 0.6+/-0.6)和治疗后,男孩的瘦素SDS高于女孩。3.在青春期前诊断的男孩和女孩中,男孩的瘦素SDS更高(1.7+/-1.3 vs. 0.2+/-1.7)。女孩的瘦素/BMI比值明显高于青春期前确诊的男孩。4. 我们发现了瘦素水平和BMI之间的相关性,并根据青春期和治疗时间对男孩和女孩进行了分析。5. 在接受和未接受颅照射的患者之间没有观察到差异。结论:急性淋巴细胞白血病的抗肿瘤治疗和疾病年龄对检查人群的体重指数和瘦素水平没有影响。
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[Relationship between body mass index and leptin levels in children treated for acute lymphoblastic leukemia during and after maintenance therapy].

Unlabelled: We analyzed the relationship between serum leptin levels and body mass index in children treated for acute lymphoblastic leukemia during and after the maintenance therapy.

Material and methods: We studied 99 survivors (62 boys) in mean age 12.65 years +/- who have been treated for ALL according to the Polish Paediatric Leukemia and Lymphoma Study Group. During the maintenance therapy there were n=34 patients (23 boys) and after treatment n=75 (39 boys). 16 patients received cranial irradiation (12 Gy). We calculated body mass index (BMI) using the formula weight/(height)2 (kg/m2). Leptin levels were measured with the RIA method. The results were expressed as SDS.

Results: 1. No difference was found in leptin SDS and BMI SDS from zero -- in the whole study group, similar in boys and girls. The leptin/BMI ratio was significantly higher in girls than in boys. 2. No differences were observed in the group during and after therapy in values of BMI SDS and leptin SDS. We found higher leptin SDS in boys during (4.86+/-1.01) and after puberty (1.53+/-0.75). We found higher leptin SDS in boys than in girls during (1.6+/-1.1 vs. 0.6+/-0.6) and after therapy. 3. In boys and girls diagnosed before puberty leptin SDS were higher in boys (1.7+/-1.3 vs. 0.2+/-1.7). The leptin/BMI ratio was significantly higher in girls than in boys diagnosed before puberty. 4. We found correlations between leptin levels and BMI in the whole group as well as in boys and girls analysed according to puberty and time of treatment. 5. No differences were observed between patients with and without cranial irradiation.

Conclusions: Anti-neoplastic treatment for acute lymphoblastic leukemia and age of disease did not influence body mass index and leptin level in the examined population.

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