Alessia Lanari MD, Giorgio Silvestrelli MD, PhD, Pierangelo De Dominicis BSc, Daniele Tomassoni MD, Francesco Amenta MD, Lucilla Parnetti MD, PhD
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Arterial Hypertension and Cognitive Dysfunction in Physiologic and Pathologic Aging of the Brain
Arterial hypertension is the most important modifiable cerebrovascular risk factor; its relationship with cerebrovascular disease is continuous, consistent, and independent. Different and probably converging pathophysiologic mechanisms explain the role of arterial hypertension in causing cognitive dysfunction in pathologic aging of the brain, specifically, vascular dementia and Alzheimer's disease.
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