{"title":"溴氰菊酯在大鼠体内的代谢。","authors":"S El-Maghraby","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To study the metabolism of 14C-deltamethrin in rats.</p><p><strong>Methods: </strong>Rats were dosed orally and i.p. with a single dose of 14C-deltamethrin (0.64 mg/Kg) body weight. The required dose was applied daily for 3 days. At the end of the experiment, selected organs, such as liver, kidney, fat, intestine, and blood were excised for radioassay of 14C-content.</p><p><strong>Results: </strong>Deltamethrin was almost eliminated from the body within 1-3 days. The main portion of 14C-residues was extracted from urine (38%, 32%) and feces (20%, 24%) with a little amount remained in various organs.</p><p><strong>Conclusion: </strong>The elimination and distribution of 14C-radioactivity in rats treated orally and intraperitoneally signify that deltamethrin is bioavailable in urine and feces.</p>","PeriodicalId":9108,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"20 3","pages":"212-6"},"PeriodicalIF":0.0000,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Metabolism of deltamethrin in rats.\",\"authors\":\"S El-Maghraby\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To study the metabolism of 14C-deltamethrin in rats.</p><p><strong>Methods: </strong>Rats were dosed orally and i.p. with a single dose of 14C-deltamethrin (0.64 mg/Kg) body weight. The required dose was applied daily for 3 days. At the end of the experiment, selected organs, such as liver, kidney, fat, intestine, and blood were excised for radioassay of 14C-content.</p><p><strong>Results: </strong>Deltamethrin was almost eliminated from the body within 1-3 days. The main portion of 14C-residues was extracted from urine (38%, 32%) and feces (20%, 24%) with a little amount remained in various organs.</p><p><strong>Conclusion: </strong>The elimination and distribution of 14C-radioactivity in rats treated orally and intraperitoneally signify that deltamethrin is bioavailable in urine and feces.</p>\",\"PeriodicalId\":9108,\"journal\":{\"name\":\"Biomedical and environmental sciences : BES\",\"volume\":\"20 3\",\"pages\":\"212-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical and environmental sciences : BES\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical and environmental sciences : BES","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Objective: To study the metabolism of 14C-deltamethrin in rats.
Methods: Rats were dosed orally and i.p. with a single dose of 14C-deltamethrin (0.64 mg/Kg) body weight. The required dose was applied daily for 3 days. At the end of the experiment, selected organs, such as liver, kidney, fat, intestine, and blood were excised for radioassay of 14C-content.
Results: Deltamethrin was almost eliminated from the body within 1-3 days. The main portion of 14C-residues was extracted from urine (38%, 32%) and feces (20%, 24%) with a little amount remained in various organs.
Conclusion: The elimination and distribution of 14C-radioactivity in rats treated orally and intraperitoneally signify that deltamethrin is bioavailable in urine and feces.
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