Methods of electroencephalographic signal analysis for detection of small hidden changes.

The aim of this study was to select and evaluate methods sensitive to reveal small hidden changes in the electroencephalographic (EEG) signal. Two original methods were considered.Multifractal method of scaling analysis of the EEG signal based on the length distribution of low variability periods (LDLVP) was developed and adopted for EEG analysis. The LDLVP method provides a simple route to detecting the multifractal characteristics of a time-series and yields somewhat better temporal resolution than the traditional multifractal analysis.The method of modulation with further integration of energy of the recorded signal was applied for EEG analysis. This method uses integration of differences in energy of the EEG segments with and without stressor.Microwave exposure was used as an external stressor to cause hidden changes in the EEG. Both methods were evaluated on the same EEG database. Database consists of resting EEG recordings of 15 subjects without and with low-level microwave exposure (450 MHz modulated at 40 Hz, power density 0.16 mW/cm2). The significant differences between recordings with and without exposure were detected by the LDLVP method for 4 subjects (26.7%) and energy integration method for 2 subjects (13.3%).The results show that small changes in time variability or energy of the EEG signals hidden in visual inspection can be detected by the LDLVP and integration of differences methods.