Wnt信号在干细胞和肺癌中的作用

B He, D M Jablons
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引用次数: 28

摘要

Wnt信号转导通路在胚胎发育、调节细胞增殖和未成熟细胞存活过程中发挥重要作用。然而,它的功能不当会给人类带来有害的后果,比如异常的细胞增殖,从而导致癌症。越来越多的证据表明,干细胞可能是导致癌症发展和增殖的突变细胞的来源。Wnt信号已被证明可以促进肠道上皮细胞和造血干细胞(hsc)的自我更新,并触发致癌的关键途径。尽管干细胞在实体瘤发展中的功能尚不清楚,但Wnt通路在决定癌症干细胞的命运和自我更新潜力方面的作用表明,它在癌变中起着关键作用。开发新的抑制剂,如抗体或小分子,来抑制这一途径可能对癌症有很大的治疗效用。
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Wnt signaling in stem cells and lung cancer.

The Wnt signal transduction pathway plays important roles during embryo development, regulating cell proliferation and survival of immature cells. However, its improper function can lead to harmful consequences for humans, such as aberrant cell proliferation and, therefore, cancer. Increasing evidence suggests that stem cells may be the source of mutant cells that cause cancers to develop and proliferate. Wnt signaling has been shown to promote self-renewal in both gut epithelial and hematopoietic stem cells (HSCs) and to trigger critical pathways in carcinogenesis. Although the function of stem cells in solid tumor development is unclear, the Wnt pathway's role in determining the fate and self-renewal potential of cancer stem cells suggests a critical role in carcinogenesis. The development of new inhibitors, such as antibodies or small molecules, to inhibit this pathway may be of great therapeutic utility against cancer.

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