蛋白质比较序列分析和计算机建模。

Brett D Hambly, Cecily E Oakley, Piotr G Fajer
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引用次数: 0

摘要

生物科学家经常遇到的一个问题是鉴定以前未知的基因或蛋白质序列,其中很少或根本没有关于生化功能,配体特异性,基因调控,蛋白质-蛋白质相互作用,组织特异性,细胞定位,活动发育阶段或生物学作用的线索。通过生物信息学的过程,现在有许多方法可以预测至少其中一些问题的答案,然后通常允许设计更有洞察力的实验来更明确地表征新蛋白质。
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Protein comparative sequence analysis and computer modeling.

A problem frequently encountered by the biological scientist is the identification of a previously unknown gene or protein sequence, where there are few or no clues as to the biochemical function, ligand specificity, gene regulation, protein-protein interactions, tissue specificity, cellular localization, developmental phase of activity, or biological role. Through the process of bioinformatics there are now many approaches for predicting answers to at least some of these questions, often then allowing the design of more insightful experiments to characterize more definitively the new protein.

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