K Rubina, E Abele, P Arsenyan, R Abele, M Veveris, E Lukevics
{"title":"含杂芳香硫化物的硅锗的合成及其降胆固醇和血管舒张剂的研究。","authors":"K Rubina, E Abele, P Arsenyan, R Abele, M Veveris, E Lukevics","doi":"10.1155/MBD.2001.85","DOIUrl":null,"url":null,"abstract":"<p><p>Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (beta-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(beta-triphenylsilylethyl) silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and vasodilating agents.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 2","pages":"85-93"},"PeriodicalIF":0.0000,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.85","citationCount":"11","resultStr":"{\"title\":\"Synthesis of silicon and germanium containing heteroaromatic sulfides as cholesterol level lowering and vasodilating agents.\",\"authors\":\"K Rubina, E Abele, P Arsenyan, R Abele, M Veveris, E Lukevics\",\"doi\":\"10.1155/MBD.2001.85\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (beta-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(beta-triphenylsilylethyl) silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and vasodilating agents.</p>\",\"PeriodicalId\":18452,\"journal\":{\"name\":\"Metal-Based Drugs\",\"volume\":\"8 2\",\"pages\":\"85-93\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/MBD.2001.85\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Metal-Based Drugs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/MBD.2001.85\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metal-Based Drugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/MBD.2001.85","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis of silicon and germanium containing heteroaromatic sulfides as cholesterol level lowering and vasodilating agents.
Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (beta-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(beta-triphenylsilylethyl) silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and vasodilating agents.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
