{"title":"肌肉注射β -胡萝卜素后猪血浆中β -胡萝卜素(胡萝卜素)和维生素A的浓度。","authors":"Gabriele Krammer, Jörg Aurich","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Limited information is available about the absorption and distribution of parenterally administered beta-carotene in pigs.Therefore plasma concentrations and pharmacokinetic parameters of beta-carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered beta-carotene preparation (Carofertin) were analysed. Five gilts were injected with a single dose of 70 mg beta-carotene in an injectable aqueous solution. The mean pre-treatment plasma beta-carotene concentration was below 10 microg/ml. After injection, plasma beta-carotene values increased rapidly and reached a peak of 13.8 +/- 5.4 microg/ml after 24 hours. For a duration of 72 hours, plasma beta-carotene concentrations were significantly increased compared to baseline values (p < 0.05).The mean half-life of beta-carotene in plasma was 7.2 +/- 1.4 hours.The single dose of 70 mg beta-carotene did not significantly affect plasma vitamin A concentrations. Tolerability and safety of the administered preparation were good. No side effects related to the medication were observed.</p>","PeriodicalId":49278,"journal":{"name":"Dtw. Deutsche Tierärztliche Wochenschrift","volume":"115 12","pages":"444-8"},"PeriodicalIF":0.0000,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Concentrations of beta-carotene (Carofertin) and vitamin A in plasma of pigs after intramuscular injection of beta-carotene.\",\"authors\":\"Gabriele Krammer, Jörg Aurich\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Limited information is available about the absorption and distribution of parenterally administered beta-carotene in pigs.Therefore plasma concentrations and pharmacokinetic parameters of beta-carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered beta-carotene preparation (Carofertin) were analysed. Five gilts were injected with a single dose of 70 mg beta-carotene in an injectable aqueous solution. The mean pre-treatment plasma beta-carotene concentration was below 10 microg/ml. After injection, plasma beta-carotene values increased rapidly and reached a peak of 13.8 +/- 5.4 microg/ml after 24 hours. For a duration of 72 hours, plasma beta-carotene concentrations were significantly increased compared to baseline values (p < 0.05).The mean half-life of beta-carotene in plasma was 7.2 +/- 1.4 hours.The single dose of 70 mg beta-carotene did not significantly affect plasma vitamin A concentrations. Tolerability and safety of the administered preparation were good. No side effects related to the medication were observed.</p>\",\"PeriodicalId\":49278,\"journal\":{\"name\":\"Dtw. Deutsche Tierärztliche Wochenschrift\",\"volume\":\"115 12\",\"pages\":\"444-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dtw. Deutsche Tierärztliche Wochenschrift\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dtw. Deutsche Tierärztliche Wochenschrift","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Concentrations of beta-carotene (Carofertin) and vitamin A in plasma of pigs after intramuscular injection of beta-carotene.
Limited information is available about the absorption and distribution of parenterally administered beta-carotene in pigs.Therefore plasma concentrations and pharmacokinetic parameters of beta-carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered beta-carotene preparation (Carofertin) were analysed. Five gilts were injected with a single dose of 70 mg beta-carotene in an injectable aqueous solution. The mean pre-treatment plasma beta-carotene concentration was below 10 microg/ml. After injection, plasma beta-carotene values increased rapidly and reached a peak of 13.8 +/- 5.4 microg/ml after 24 hours. For a duration of 72 hours, plasma beta-carotene concentrations were significantly increased compared to baseline values (p < 0.05).The mean half-life of beta-carotene in plasma was 7.2 +/- 1.4 hours.The single dose of 70 mg beta-carotene did not significantly affect plasma vitamin A concentrations. Tolerability and safety of the administered preparation were good. No side effects related to the medication were observed.