脾非霍奇金淋巴瘤表现为复发性肾结石——“偶发瘤”?

Kaushik Doshi, John Stanciu, Jose Cervantes, Lucan Rodrigues, Jonas Gintautas, Ayaz Alwani
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摘要

脾淋巴瘤,又称原发性脾恶性淋巴瘤(PMLS),是一种罕见的疾病,由于其分类方法不一,其真实性质难以界定。在所有非霍奇金淋巴瘤中,它占不到2%的病例。一些专家认为,PMLS仅累及脾脏和脾门,而另一些专家则认为,PMLS是一种在脾脏内发展的实体,后来有可能侵入邻近器官并转移。脾淋巴瘤的临床特征以非特异性全身性症状为特征,如低烧、盗汗和与脾肿大相关的症状。这些淋巴瘤大多为b细胞起源,组织学分析显示为低或中度淋巴瘤。我们在这里提出的病例是一个病人表现为左侧腰痛,并考虑到既往的肾结石病史,可能是一个简单的诊断肾结石。然而,进一步的调查导致发现脾淋巴瘤,早期无症状,但可能表现出类似肾绞痛的症状。
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Splenic non-Hodgkin's lymphoma presenting as recurrent kidney stones -- an "incidentaloma"?

Splenic lymphoma, or primary malignant lymphoma of the spleen (PMLS), is an uncommon condition whose true nature is difficult to define due to the variable ways it has been classified. Out of all non-Hodgkin's lymphomas it comprises less than 2% of cases. Some experts suggest that PMLS only involves the spleen and splenic hilum, while others consider PMLS to be an entity that develops within the spleen and later has the potential for invading adjacent organs and metastasizing. Clinical features of splenic lymphoma are characterized by nonspecific systemic symptoms such as low grade fevers, night sweats and symptoms related to considerable splenomegaly. Most of these lymphomas are of B-cell origin showing low or intermediate-grade lymphoma on histological analysis. The case we present here is of a patient presenting with left sided flank pain, and given a previous history of nephrolithiasis, a presumably simple diagnosis of kidney stones was made. However, further investigation led to the discovery of splenic lymphoma, which was asymptomatic earlier but may have manifested symptoms that mimicked renal colic.

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