可卡因急性毒性的机理。

Kennon Heard, Robert Palmer, Nancy R Zahniser
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引用次数: 0

摘要

急性可卡因中毒患者会出现危及生命的症状,涉及多个器官系统。虽然可卡因的作用多种多样,但它们都是可卡因与有限数量的蛋白质相互作用的结果,包括单胺转运体、神经递质受体和电压门控离子通道。这些主要的相互作用会引发一系列事件,最终产生临床效应。本文旨在回顾可卡因的主要相互作用以及这些相互作用引发的效应。我们还描述了可卡因中毒症状的发展与血清可卡因浓度的关系。
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Mechanisms of acute cocaine toxicity.

Patients with acute cocaine poisoning present with life-threatening symptoms involving several organ systems. While the effects of cocaine are myriad, they are the result of a limited number of cocaine-protein interactions, including monoamine transporters, neurotransmitter receptors and voltage-gated ion channels. These primary interactions trigger a cascade of events that ultimately produce the clinical effects. The purpose of this article is to review the primary interactions of cocaine and the effects that these interactions trigger. We also describe the progression of symptoms observed in cocaine poisoning as they relate to serum cocaine concentrations.

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