用5-取代脱氧胞苷制备新的DNA三联体。

Nucleic acids symposium series (2004) Pub Date : 2009-01-01 DOI:10.1093/nass/nrp082

Takashi Kanamori, Hirosuke Tsunoda, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio

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摘要

我们开发了一种新的人工DNA三联体，它在第一条链上含有腺嘌呤核碱基。该三联体(A-psi-C*)由腺嘌呤、假尿嘧啶和5-取代胞嘧啶分别作为第一、第二和第三链核碱基组成。本文还描述了二链和三链的核碱基的分子设计和合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Development of new DNA triplex triads by using 5-substituted deoxycytidine.

We developed a new artificial DNA triplex triad which has the adenine nucleobase in the first strand. This triplex triad (A-psi-C*) is composed of adenine, pseudouridine and 5-sudstituted cytosine as the 1st, 2nd and 3rd strand nucleobases, respectively. The molecular design and synthesis of the nucleobases for the 2nd and 3rd strand of the triplex are also described.

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Nucleic acids symposium series (2004)

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