[硫代蒽酮的磺化衍生物，一类用于微阵列寡核苷酸合成的新型光去三烷基化剂]。

Bioorganicheskaia khimiia Pub Date : 2010-01-01

A N Siniakov, A A Riabinin, G A Maksakova, V V Shelkovnikov, V A Loskutov, E V Vasil'ev, N V Shekleina

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引用次数: 0

摘要

为了寻找微阵列低聚脱氧核糖核苷酸合成的新型去三烷基化试剂，研究了一类新的光酸，即基于硫代蒽酮的六磷酸磺酸在低聚核苷酸合成过程中去除二甲氧基三烷基保护基团的可用性。2,4-二乙基-9-氧-10-(4-庚氧基苯基)- 9h -六氟磷酸硫代蒽醌已成功用于固相合成(dT)(10)。

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[Sulfonium derivatives of thioxanthenone, a new class of photodetritylating agents for microarray oligonucleotide synthesis].

The usability of a new class of photo acids, namely, sulfonium hexaphosphates based on thioxanthenone, for the removal of the dimethoxytrityl protective group in the process of oligonucleotide synthesis has been studied in order to search for new detritylating agents for microarray oligodeoxyribonucleotide synthesis. 2,4-Diethyl-9-oxo-10-(4-heptyloxyphenyl)-9H-thioxanthenium hexafluorophosphate has been successfully used for the solid-phase synthesis of (dT)(10).

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Bioorganicheskaia khimiia

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