在猪模型中,胆囊内引流防止急性胆囊炎的发展:一项随机研究。

Daniel W Kjaer, Frank V Mortensen, Jens K Møller, Stephen J Hamilton-Dutoit, Peter Funch-Jensen
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引用次数: 4

摘要

背景:急性胆囊炎可能是胆汁潴留在胆囊的结果,并可能继发感染和缺血。本研究的目的是研究在猪模型中胆囊内引流是否可以防止急性胆囊炎的发生。材料和方法:20头猪随机分为内引流组(引流组)和不引流组(不引流组)。第0天,结扎囊性动脉、胆管并接种细菌诱导急性胆囊炎。四天后,猪被杀死,胆囊被切除,组织学评分是否存在胆囊炎。采集胆汁和血液样本进行细菌培养和生化分析。结果:组织学检查显示两组间急性胆囊炎的发展有统计学意义,未排水猪的炎症程度最高。两组之间的细菌培养没有差异。结论:胆囊内引流对猪急性胆囊炎的发生有保护作用。这些发现支持了胆囊结石嵌塞在急性胆囊炎发病机制中起重要作用的理论,提示内引流可能是预防和治疗急性胆囊炎的一种方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Internal gallbladder drainage prevents development of acute cholecystitis in a pig model: a randomized study.

Background: Acute cholecystitis can be the result of retention of bile in the gallbladder with possible secondary infection and ischaemia. The aim of the present study was to investigate whether internal drainage of the gallbladder could protect against the development of acute cholecystitis in a pig model.

Materials and methods: Twenty pigs were randomized to either internal drainage (drained) or not (undrained). Day 0 acute cholecystitis was induced by ligation of the cystic artery and duct together with inoculation of bacteria. Four days later the pigs were killed and the gallbladders were removed and histologically scored for the presence of cholecystitis. Bile and blood samples were collected for bacterial culturing and biochemical analyses.

Results: The histological examination demonstrated statistical significant differences in acute cholecystitis development between groups, the degree of inflammation being highest in undrained pigs. There were no differences in bacterial cultures between the two groups.

Conclusion: Internal drainage of the gallbladder protected against the development of acute cholecystitis in the present pig model. These findings support the theory that gallstone impaction of the cystic duct plays a crucial role as a pathogenetic mechanism in the development of acute cholecystitis and suggest that internal drainage may be a way to prevent and treat acute cholecystitis.

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