{"title":"2例三发淋巴瘤的易位(3;8)(q27;q24)","authors":"Cristina Motlló , Javier Grau , Jordi Juncà , Neus Ruiz , José-Luis Mate , Elisa Orna , José-Tomás Navarro , Susana Vives , Juan-Manuel Sancho , Daniel Esteban , Isabel Granada , Evarist Feliu , Josep-Maria Ribera , Fuensanta Millá","doi":"10.1016/j.cancergencyto.2010.08.018","DOIUrl":null,"url":null,"abstract":"<div><p>Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This lymphoma usually shows <em>MYC</em> rearrangements with non-<em>IGH</em> genes in the setting of a complex karyotype possibly involving <em>BCL2</em> and, less frequently, <em>BCL6</em> rearrangements. According to the presence of two or three rearrangements, these lymphomas are called double-hit lymphomas or triple-hit lymphomas (THL), respectively. Here we report two cases of THL with <em>MYC</em>, <em>BCL2</em>, and <em>BCL6</em> rearrangements and t(3;8)(q27;q24) diagnosed in one center in the last two years.</p></div>","PeriodicalId":55596,"journal":{"name":"Cancer Genetics and Cytogenetics","volume":"203 2","pages":"Pages 328-332"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cancergencyto.2010.08.018","citationCount":"21","resultStr":"{\"title\":\"Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma\",\"authors\":\"Cristina Motlló , Javier Grau , Jordi Juncà , Neus Ruiz , José-Luis Mate , Elisa Orna , José-Tomás Navarro , Susana Vives , Juan-Manuel Sancho , Daniel Esteban , Isabel Granada , Evarist Feliu , Josep-Maria Ribera , Fuensanta Millá\",\"doi\":\"10.1016/j.cancergencyto.2010.08.018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This lymphoma usually shows <em>MYC</em> rearrangements with non-<em>IGH</em> genes in the setting of a complex karyotype possibly involving <em>BCL2</em> and, less frequently, <em>BCL6</em> rearrangements. According to the presence of two or three rearrangements, these lymphomas are called double-hit lymphomas or triple-hit lymphomas (THL), respectively. Here we report two cases of THL with <em>MYC</em>, <em>BCL2</em>, and <em>BCL6</em> rearrangements and t(3;8)(q27;q24) diagnosed in one center in the last two years.</p></div>\",\"PeriodicalId\":55596,\"journal\":{\"name\":\"Cancer Genetics and Cytogenetics\",\"volume\":\"203 2\",\"pages\":\"Pages 328-332\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.cancergencyto.2010.08.018\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Genetics and Cytogenetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165460810004814\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Genetics and Cytogenetics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165460810004814","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma
Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This lymphoma usually shows MYC rearrangements with non-IGH genes in the setting of a complex karyotype possibly involving BCL2 and, less frequently, BCL6 rearrangements. According to the presence of two or three rearrangements, these lymphomas are called double-hit lymphomas or triple-hit lymphomas (THL), respectively. Here we report two cases of THL with MYC, BCL2, and BCL6 rearrangements and t(3;8)(q27;q24) diagnosed in one center in the last two years.
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