[合成三萜酰化物——一种有效抑制甲型H1N1流感病毒和乳头瘤病毒繁殖的物质]。

Bioorganicheskaia khimiia Pub Date : 2010-11-01

O B Kazakova, N I Medvedeva, I P Baĭkova, G A Tolstikov, T V Lopatina, M S Iunusov, L Zaprutko

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引用次数: 0

摘要

以齐墩果酸、甘草酸、熊果酸和白桦脂为原料合成了一类新的三萜酰化物。对合成的化合物与呼吸道感染病毒病原体繁殖的关系进行了活性研究，28- o -甲氧基辛酸白桦林对甲型H1N1流感具有较高的活性，选择性指数SI > 100。检测到3,28-二烟碱白桦素对HPV-11株乳突瘤病毒的高活性，选择性指数SI为35。

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[Synthesis of triterpenoid acylates - an effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses].

The synthesis of a new group of triterpenoid acylates on the basis of oleanolic, glycyrrhetic and ursolic acids and betulin is described. In studying the activity of the synthesized compounds in relation to reproduction of virus pathogens of respiratory infections 28-O-methoxycynnamoylbetulin shows high activity against influenza type A (H1N1) the selectivity index SI > 100. The high activity of 3,28-dinicotinoylbetulin against papilloma virus (strain HPV-11) was detected, the selectivity index SI was 35.

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Bioorganicheskaia khimiia

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