劳伦斯·大卫·霍尔。

Bruce Coxon
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引用次数: 0

摘要

介绍了劳伦斯·戴维·霍尔(1938-2009)的生平、科学贡献和逝世,包括他在英国布里斯托尔大学的早期历史和教育,以及在加拿大温哥华不列颠哥伦比亚大学从事研究和教学的20年间碳水化合物和其他天然产物的合成和核磁共振波谱。提供了这一时期的研究生、博士后研究员和休假访问者名单。在Herchel Smith博士的慷慨捐赠下,Hall教授在英国剑桥大学建立了一个新的药物化学系,并极大地扩展了他在磁共振成像(MRI)和零量子核磁共振技术和应用方面的研究。MRI技术不仅应用于医学问题,如膝关节软骨退行性变的表征、心室功能的测量、动脉粥样硬化动物模型中的脂质定位、作为对比剂的顺磁性多糖金属配合物以及许多其他解剖学特征的研究,而且还应用于材料分析的几个方面,包括食品分析、过程控制、阐明了诸如液体在多孔介质中的流动、混凝土中的缺陷以及木材真菌损伤的可视化等物理现象。霍尔教授的许多出版物、专利、讲座、荣誉和奖项都被描述,以及他成功的努力,以保持Asilomar设施在太平洋格罗夫,加利福尼亚作为年度实验核磁共振会议的交替场地。为霍尔教授举行了两次追悼会。
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Laurance David Hall.

An account is given of the life, scientific contributions, and passing of Laurance David Hall (1938-2009), including his early history and education at the University of Bristol, UK, and the synthesis and NMR spectroscopy of carbohydrates and other natural products during ∼20 years of research and teaching at the University of British Columbia in Vancouver, Canada. Lists of graduate students, post-doctoral fellows, and sabbatical visitors are provided for this period. Following a generous endowment by Dr. Herchel Smith, Professor Hall built a new Department of Medicinal Chemistry at Cambridge University, UK, and greatly expanded his researches into the technology and applications of magnetic resonance imaging (MRI) and zero quantum NMR. MRI technology was applied both to medical problems such as the characterization of cartilage degeneration in knee joints, the measurement of ventricular function, lipid localization in animal models of atherosclerosis, paramagnetic metal complexes of polysaccharides as contrast agents, and studies of many other anatomical features, but also to several aspects of materials analysis, including food analyses, process control, and the elucidation of such physical phenomena as the flow of liquids through porous media, defects in concrete, and the visualization of fungal damage to wood. Professor Hall's many publications, patents, lectures, and honors and awards are described, and also his successful effort to keep the Asilomar facility in Pacific Grove, California as the alternating venue for the annual Experimental NMR Conference. Two memorial services for Professor Hall are remembered.

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来源期刊
Advances in carbohydrate chemistry and biochemistry
Advances in carbohydrate chemistry and biochemistry 生物-生化与分子生物学
CiteScore
2.20
自引率
0.00%
发文量
0
期刊介绍: Advances in Carbohydrate Chemistry and Biochemistry has provided, since its inception in 1945, critical and informative articles written by research specialists that integrate the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology to the study of carbohydrates. Its articles present a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.
期刊最新文献
Towards one-pot selective synthesis of cyclic oligosaccharides. Pseudo-glycoconjugates with a C-glycoside linkage. Conformationally restricted donors for stereoselective glycosylation. Boron-mediated aglycon delivery (BMAD) for the stereoselective synthesis of 1,2-cis glycosides. Therapeutic in vivo synthetic chemistry using an artificial metalloenzyme with glycosylated human serum albumin.
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